[1] Yang Jiahao Xu Jianhu,.Effect of the Therapy of Warming Yang to Resolve Fluid Retention on Serum ANP, TNF -α and IL -6 Levels in Rats with Chronic Heart Failure [J]. Modern Traditional Chinese Medicine, 2019, (02): 92-95. [doi: 10.13424/j.cnki.mtcm.2019.02.028]
Effect of the Therapy of Warming Yang to Resolve Fluid Retention on Serum ANP, TNF -α and IL -6 Levels in Rats with Chronic Heart Failure
- Article number:
- 1672-0571(2019)02-0092-04
- ZTFLH:
- R258.5
- Code:
- A
- Abstract:
- To explore the effect of the therapy of warming yang to resolve fluid retention on Serum ANP, TNF - α and IL -6 Levels in Rats with chronic heart failure. Method Forty healthy male SD rats were randomly divided into blank group ( 10 rats) and CHF group ( 30 rats) . Rats in CHF group were injected intraperitoneally with adriamycin ( ADR) to replicate chronic heart failure model. After the model establishment, SD rats in CHF group were randomly divided into model group, warming yang to resolve fluid retention group and metoprolol group for intervention. After four weeks, the pathological changes of myocardium were observed and the serum ANP of rats, concentrations of TNF – alpha and IL -6 in each group were determined. Result Compared with the blank group, the contents of ANP, TNF - alpha and IL -6 in the model group increased ( P < 0. 01) . Compared with the model group, the contents of TNF - alpha and IL -6 in the warming yang to resolve fluid retention group and the metoprolol group decreased ( P < 0. 01) . Compared with the warming yang to resolve fluid retention group, the contents of IL -6 in the metoprolol group increased ( P < 0. 05) .Conclusion The therapy of warming yang to resolve fluid retention can significantly reduce the levels of TNF - alpha and IL -6 in serum of CHF rats, inhibit inflammatory reaction and improve cardiac function.
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Memo
基金项目：宁夏高等学校科学研究项目（ＮＧＹ２０１７１１９）