[1] Niu Danqing Xu Pengchong Zhang Jingming,.Effects of Zuogui and Yougui Pills on Learning and Memory and ERK Protein Expression in Hippocampus of Rats with Kidney Deficiency [J]. Modern Traditional Chinese Medicine, 2019, (02): 101-103. [doi: 10.13424/j.cnki.mtcm.2019.02.030]
Effects of Zuogui and Yougui Pills on Learning and Memory and ERK Protein Expression in Hippocampus of Rats with Kidney Deficiency
- Article number:
- 1672-0571(2019)02-0101-03
- Keywords:
- ERK; kidney deficiency; learning and memory; Zuogui Pill; Yougui Pill
- ZTFLH:
- R285.5
- Code:
- A
- Abstract:
- To investigate the effects of Zuogui and Yougui Pills on learning and memory ability and extracellular signal - regulated kinase ( ERK) content in hippocampus of rats with kidney deficiency. Method The rat model of kidney deficiency was established by the method of ＂cat frightening mice＂. After the rats gave birth, the offspring were divided into blank group, model group, Zuogui pill group and Yougui pill group, and were continued to be intimidated and treated with kidney tonifying drugs. Result ( 1) Morris water maze test: Compared with the blank control group, the escape latency, total distance and the first time to cross the target of kidney deficiency model group were prolonged, and the residence time of target area was decreased ( P <0. 05) ; Compared with kidney deficiency model group, the escape latency, total distance and first time to cross the target of Zuogui pill group and Yougui pill group were shortened, and the residence time of target area was increased. ( P <0. 05) . ( 2) Enzyme - linked immunosorbent assay ( ELISA) for ERK protein expression: Compared with the blank group, the content of ERK protein in the hippocampus of rats in the kidney deficiency model group was significantly lower ( P <0. 05) , and the content of ERK protein in Zuogui and Yougui pills group was significantly higher than that in the kidney deficiency model group ( P <0. 05) . Conclusion Zuogui and Yougui Pills with the function of tonifying kidney can improve the learning and memory ability of rats with kidney deficiency by regulating the expression of extracellular signal - regulated kinase ( ERK) in hippocampus.
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基金项目：陕西省教育厅重点实验室科研计划项目（１６ＪＳ０２７）