[1] Zhang Qi, Shao Jie, Shi Linying, et al. The Influence of Ethanol Extract of Rhizoma Cynanchae on the Callus of Rats, Serum Ca, P and AKP in Tibial Bone Defect Model [J]. Modern Traditional Chinese Medicine, 2020, (04): 9-12/19. [doi: 10.13424/j.cnki.mtcm.2020.04.003]
The Influence of Ethanol Extract of Rhizoma Cynanchae on the Callus of Rats, Serum Ca, P and AKP in Tibial Bone Defect Model
- Article number:
- 1672-0571(2020)04-0009-05
- Keywords:
- open fracture; porosis; the ethanol extract of rhizoma cynanchae; Ca; P; Akp
- ZTFLH:
- R274.1
- Code:
- A
- Abstract:
- Objective To explore the influence of ethanol extracts of rhizoma cynanchae on the fracture repair in rats through an observaion of the influence of extracts on the porosis, Serum Ca, P and AKP in the healing process of tibial bone defect in rats. Method To carry out tibial bone defect plasty to the rats and randomly divide the successful modeling rats into the model group, ethanol group, and bone joiner group, and each group is further divdided into 3 subgroups according to the time of medication( the groups of 2, 4, and 8 weeks ) . The model group is given the intragastric administration by normal saline; the ethnol group is given the intragastric administration by the extracts ; the last one is given the intragastric administration by Shangke Jiegu Tablets. After the 2, 4 and 8 weeks, the x - ray is used to observe the porosis and evaluate the Serum Ca, P and AKP. Result The tibial defect in rats of the ethanol group almost disappears and the volume of porosis is higher than the other groups; Serum Ca, P and AKP is higher than the other two groups at various times( p <0. 05) ; serum P concentration in the ethnol group is lower than the other two at various times( p < 0. 05) .Conclusion The ethanol extract of rhizoma cynanchae is effective in treating the tibial defect in rats.
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Memo
基金项目:2017地方高校陕西省大学生创新创业训练计划项目(2225)
通讯作者:党琳,教授?E-mail:dlinmen@163.com