[1] Wei Zhuangyi, Ren Xiaopeng, Zhang Yong, et al. Effect of Qingfu Tongchang Granule on TNF - α and NF – κB p65 in ALI Rats [J]. Modern Traditional Chinese Medicine, 2020, (06): 20-24,41. [doi: 10.13424/j.cnki.mtcm.2020.06.005]
Effect of Qingfu Tongchang Granule on TNF - α and NF – κB p65 in ALI Rats
- Article number:
- 1672-0571(2020)06-0020-06
- Keywords:
- Qingfu Tongchang Granules; TNF - α; NF - κBp65; pyemia; ALI
- ZTFLH:
- R256.1
- Code:
- A
- Abstract:
- Objective To observe the effect of Qingfu Tongchang( clearing lung and dredging intestine) Granule on ALI ( acute lung injury) in rats with pyemia. Methods A pyemia rat model was established by injecting LPS into the tail vein of 40 rats, and then they were randomly divided into 4 groups ( n =10) : blank group, model group, dexamethasone control group, and Qingfu Tongchang group. 2 days after modeling, the pathological changes of lung tissue were observed under light microscope by HE staining method and serum TNF - α content was detected by ELISA method. Western – blot method was used to measure the expression of NF - κB p65 in lung tissue. Results The serum TNF - α level in the Qingfu Tongchang group was significantly lower than that of the model group ( P <0. 05) . The lung tissue W/ D, NF - κB p65 expression and lung tissue injury scores of the Qingfu Tongchang group were significantly lower than those of the model group ( P <0. 05) . Conclusion Qingfu Tongchang Granule can effectively protect lung tissue damage by reducing the degree of lung inflammation.
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Memo
基金项目:陕西省中医药管理为中医科研项目中医临床研究课题(JCMS045)
通讯作者:任小朋,主任医师?E-mail:1055613232@qq.com