[1] NIZhitao, DUXiaofengSHIYupan, SHANGTing, et al. TechnologicalImprovementofDahuangXiaozhiSuppositoryandDeterminationofItsActiveComponents [J]. Modern Traditional Chinese Medicine, 2021, (03): 34-38. [doi: 10.13424/j.cnki.mtcm.2021.03.008]
TechnologicalImprovementofDahuangXiaozhiSuppositoryandDeterminationofItsActiveComponents
- Article number:
- 1672-0571(2021)03-0034-05
- ZTFLH:
- R943
- Code:
- A
- Abstract:
- Objective:ToimprovethepreparationtechnologyofDahuangXiaozhisuppositoryanddeterminethecontentofeffectivecomponents.Methods:Onthepremiseofsuppositoryforming,theproportionofmixedfattyacidglycerideandbeeswax,pouringtemperatureandcoolingtimeofdemouldingweretakenasthefactors,andtheappearance,weightdifferenceandmeltingtimeofsuppositoryweretakenastheevaluationindexes.Thequaliyofsuppositorywasevaluatedbycomprehensivescoringmethod,andthebestpreparationprocesswasoptimized.FiveanthraquinonesinRhubarbweredeterminedbyHPLC.Theconentsofemodin,rhein,emodin,chrysophanolandphyscionweredetermined.Results:TheoptimalpreparationprocessofDahuangXiaozhisuppositorywasasfollows:mixedfattyacidglyceride:beeswax=8∶1,injectiontemperature:75℃,roomtemperaturecoolingdemouldingtime:5min;aloeemodin,rhein,emodin,chrysophanol,physcionwere2.25~36.00μg·ml-1,1.36~21.76μg·ml-1,1.90~30.40μg· ml-1 ,1.90~30.40μg· ml-1 ,0.70~11.20μg· ml-1 ,respectively.Therewasagoodlinearrelationshipbetweentheconcentrationrangeandthepeakarea(r=0.9995,0.9996,0.9996,0.9995,0.9997),theRSDvaluesofprecisionandrepeatabilitywerelessthan2%,theRSDvaluesofpeakareawithin12hwerelessthan2%,andtheaveragerecoverieswere96.0%-103.5%,RSDvalueswerelessthan2%.Conclusion:DahuangXiaozhisuppositorypreparedbythisprocesshasgoodformability,noneedoffreezing,shorttimeofdemouldingatroomtemperature,weightdifferenceandmeltingtime,andhighfeasibility;thecontentdeterminationmethodhasgoodrepeatability,strongspecificityandreliableresults,whichcanbeusedforthequalitycontrolofthesuppository
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Memo
基金项目：２０１８年全国中药特色技术传承人才培训项目（Ｔ２０１８４８２８００５）