Pre Next

[1] MA Yilin YU Hong SUN Shi WU Xiaolong,.Study on Quality Standard of Femoral Head Necrotic Capsule [J]. Modern Traditional Chinese Medicine, 2021, (04): 22-26. [doi: 10.13424/j.cnki.mtcm.2021.04.005]

Copy

Study on Quality Standard of Femoral Head Necrotic Capsule

Modern Traditional Chinese Medicine[ISSN: 1006-6977/ CN: 61-1281/TN] Volumes & Issues: 2021 04 pagination: 22-26 Column: Publication date: 2023-11-20

Article number:: 1672-0571(2021)04-0027-05

Author(s):: MA Yilin YU Hong SUN Shi WU Xiaolong; Henan Luoyang Orthopedic Hospital/Henan Orthopedic Hospital，Henan Luoyang 471002,China

Keywords:: Femoral head necrosis capsule; Quality standard; Thin layer chromatography; High performance liquid chromatography

ZTFLH:: R286

DOI:: 10.13424/j.cnki.mtcm.2021.04.005

Code:: A

Abstract:: Objective To improve the quality standard of femoral head necrotic capsule. Methods Radix salviae miltiorrhizae，Ramulus Cinnamomi and Fructus Psoraleae were identified by TLC; The content of dracorhodin in dracorhodin preparation was determined by HPLC: chromatographic conditions: kromosal 100-5-C18 column，column temperature 40 ℃，mobile phase: acetonitrile-0.05 mol·L-1sodium dihydrogen phosphate solution (35∶65)，detection wavelength: 440 nm，flow rate: 1 mL·min-1 . Injection volume 10μL. Results TLC spots of Salvia miltiorrhiza，Ramulus Cinnamomi and Psoralea corylifolia were clear and well separated without negative interference; The content of dracorhodin ranged from 2.08 to 41.68 μg·mL-1. There was a linear relationship (r=0.9997). The RSD of precision，stability and repeatability were less than 3%，and the average recovery was 99.46%，RSD=1.38%.Conclusion The quality standard established in this study is accurate and reliable，which can be used for the quality control of femoral head necrotic capsule.

References:

［1］黄婧.股骨头缺血性坏死的中药治疗进展［J］.中国预防医学杂志,2009,10(2):154-156.

［2］何海军,陈卫衡.将生存质量引入中医药治疗股骨头坏死疗效评价体系的思考［J］.中国中医骨伤科杂志,2009,17(4):62-63.

［3］李刚,王均玉.股骨头坏死的中医认识与研究现状［J］.山西中医,2010,26(5):52-54.

［4］熊屹.孙成榆教授治疗股骨头缺血坏死的经验［J］.贵阳中医学院学报,2007,29(4):15-16.

［5］王冬雪,马丽.股骨头坏死的中医辨证及治疗进展［J］.世界中西医结合杂志,2008,3(12):747-749.

［6］马勇,王培民.许建安治疗股骨头缺血性坏死的经验［J］.江苏中医药,2008,40(11):16-17.

［7］周正新,刘安平,王峰,等.丁锷论治股骨头缺血性坏死的学术特点［J］.中医药临床杂志,2007,19(3):209-210.?

［8］王进,张翀,邱少波.从藏象理论论股骨头缺血性坏死之防治［J］.辽宁中医药大学学报,2008,10(11):35-37.

［9］乔德荣,刘红,吕海潮.股骨头坏死的病因病机与诊治:袁浩教授临床经验总结［J］.内蒙古中医药,2006,25(4):23-24.

［10］谭旭仪,刘又文,高书图,等.股骨头坏死愈胶囊治疗股骨颈骨折术后患者55例临床观察［J］.中医杂志,2014,55(4):308-310.

［11］吴晓龙.股骨头坏死愈胶囊治疗肝肾两虚型股骨头缺血性坏死120例疗效观察［J］.中医药临床杂志,2013,25(10):876.

［12］王丹丹,杨艳梅,王庆丰.股骨头坏死愈胶囊修复股骨头坏死的作用机制探讨［J］.中医药导报,2019,25(8):122-125.

［13］徐淑卿,沙明,孟宪生.血竭的稳定性研究［J］.中成药,2005,27(5):598-599.

［14］吴敏.高温环境对血竭质量稳定性的影响［J］.实用中医药杂志，2017,23(11):741.

［15］国家药典委员会.中华人民共和国药典.四部［M］.北京:中国医药科技出版社,2020:57.

［16］吴星.股骨头坏死愈胶囊治疗股骨头坏死(气虚瘀滞型)的临床观察［D］.郑州:河南中医药大学,2016.

［17］李欣,尹燕杰.含血竭的部分中成药质量控制问题及建议［J］.中国药事,2012,26(12):1369-1371.

［18］潘彦荣,王爽,刘艳霞,等.HPLC法测定活血壮筋丸中血竭素的含量测定［J］.首都食品与医药,2020,27(2):189-191.

［19］叶星辰,班俊峰,吕竹芬,等.竭红跌打巴布剂中血竭素的含量测定［J］.中国医药指南,2019,17(22):7-9.

［20］徐雄华,胡珊梅.HPLC法测定化瘀止痛散中血竭素的含量［J］.海峡药学,2011,23(9)：69-71.

Memo

基金项目：河南省中医药科学研究专项（2018ZY2021）

Last Update: 2021-08-02