[1] CUI Lei GAO Le,.Study on The Mechanism of Ningshen Zhijing Decoction in Treatment of Cerebral Vasospasm After Intervention of aSAH [J]. Modern Traditional Chinese Medicine, 2022, 1(01): 133-136. [doi: 10.13424/j.cnki.mtcm.2022.01.027]
Study on The Mechanism of Ningshen Zhijing Decoction in
Treatment of Cerebral Vasospasm After Intervention of aSAH
- Article number:
- 1672-0571(2022)01-0133-04
- ZTFLH:
- R246.1
- Code:
- A
- Abstract:
- Abstract：Objective To study the effect and mechanism of Ningshen Zhijing decoction in the treatment of cerebral vasospasm after intervention of aSAH. Methods 63 patients after aSAH intervention were randomly divided into two groups, including 33 cases in the treatment group and 30 cases in the control group. Both groups were treated with nimodipine pump and routine treatment. On this basis, the treatment group was treated with Ningshen Zhijing decoction once a day. Both groups were treated for 14 days. ET-1 and S100-β in different periods were detected. The changes of Vm, Linde-gard and PI were examined by TCD, and the rate of new cerebral infarction on brain CT was compared. Results Serum level of ET-1,S100-β and Vm, Linde-gard,PI detected by TCD at admission in the two groups had no significant difference (P>0.05).The levels of ET-1 and S100-β in the treatment group were significantly lower than those in the control group after treatment (P＜0. 05）；The levels of Vm, Linde-gard and PI in the treatment group were significantly lower than those in the control group after treatment and on the 7th and 14th day (P<0.05). There were 2 cases (6.1%) of new cerebral infarction in the treatment group and 4 cases (13.3%) in the control group. The rate of new cerebral infarction in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Ningshen Zhijing decoction combined with nimodipine can effectively reduce the degree of cerebral vasospasm and the incidence of new cerebral infarction in patients after aSAH intervention, and its mechanism may be related to the reduction of ET-1 and S100-β Level, improve vascular endothelial function and prevent brain cell injury.
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Memo
基金项目：国家自然科学基金项目（81673832）