Pre Next

PDF Download

[1] KONG JingZHOU Bingtuo TANG Jin HE Cong TANG YishuangWANG Xiaosu PAN Xudi LIU Xia JI Jing,.Effect of Qingxia Huayu Formula Combined with ConventionalWestern Medicine Therapy on Endotoxins，PCT，IL-6，and IL-10 in Patients with Moderateto Severe Acute Pancreatitis [J]. Modern Traditional Chinese Medicine, 2023, (05): 63-68. [doi: 10.13424/j.cnki.mtcm.2023.05.013]

Copy

Effect of Qingxia Huayu Formula Combined with ConventionalWestern Medicine Therapy on Endotoxins，PCT，IL-6，and IL-10 in Patients with Moderateto Severe Acute Pancreatitis

Modern Traditional Chinese Medicine[ISSN: 1006-6977/ CN: 61-1281/TN] Volumes & Issues: 2023 05 pagination: 63-68 Column: Publication date: 2023-09-20

Article number:: 1672-0571(2023)05-0063-06

Author(s):: KONG Jing¹; 2ZHOU Bingtuo¹; 2 TANG Jin¹; 2 HE Cong¹; 2 TANG Yishuang1WANG Xiaosu¹; 2 PAN Xudi¹ LIU Xia1 JI Jing¹; 1.Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to ShanghaiUniversity of Traditional Chinese Medicine，Shanghai 200437,China；
2.Digestive Disease Research Laboratory of Integrated Traditional Chinese and Western Medicine，Shanghai 200437,China

Keywords:: Key words:Acute pancreatitis; Qingxia Huayu formula; Endotoxins; Procalcitonin; Inflammatory mediators

ZTFLH:: R256.39

DOI:: 10.13424/j.cnki.mtcm.2023.05.013

Code:: A

Abstract:: Abstract：Objective To evaluate the effect of Qingxia Huayu formula on endotoxin，PCT，IL-6，and IL-10 in patients with acute pancreatitis，and to clarify its antiinflammatory effect.Methods Sixty MSAP or SAP patients were divided into a treatment group of 30 cases and a control group of 30 cases.The control group was treated with conventional Western medicine，while the treatment group was supplemented with Qingxia Huayu formula.After 7 days of treatment，both groups were tested for endotoxin，PCT，cytokines (such as IL-6 and IL-10) to observe clinical efficacy.Results Compared with the control group，the treatment group significantly reduced the levels of gut derived endotoxins，procalcitonin，and IL-6 in AP patients (P<0.01)，while the two groups had no statistically significant impact on IL-10 levels (P>0.05).Conclusion Early combination of Qingxia Huayu formula nasal feeding can reduce intestinal endotoxin translocation，reduce the release of inflammatory mediators，alleviate SIRS，and reduce the incidence of MODS.

References:

［1］Vege SS,Gardner TB,Chari ST,et al.Low mortality and high morbidity in severe acute pancreatitis without organ failure:a case for revising the Atlanta classification to include “moderately severe acute pancreatitis”［J］.The American Journal of Gastroenterology,2009,104(3):710-715.
［2］中华医学会消化病学分会胰腺疾病学组,《中华胰腺病杂志》编辑委员会,《中华消化杂志》编辑委员会.中国急性胰腺炎诊治指南(2019,沈阳)［J］.中华胰腺病杂志,2019,19(5):35-38.
［3］孔婧,王晓素,周秉舵,等.中西医结合疗法治疗急性胰腺炎临床观察［J］.上海中医药杂志,2015,49(12):39-41.
［4］周秉舵,方盛泉,朱生樑,等.清下解胰方鼻饲加灌肠联合西药治疗重症急性胰腺炎临床观察［J］.上海中医药杂志,2015,49(4):44-46.
［5］周秉舵,徐亭亭,孔婧,等.清下解胰方改善重症胰腺炎患者肠屏障功能的临床研究［J］.上海中医药大学学报,2015,29(1):33-36.
［6］王兴鹏,李兆申,袁耀宗,等.中国急性胰腺炎诊治指南(2013,上海)［J］.中国实用内科杂志,2013,33(7):530-535.
［7］Glasbrenner B,Adler G.Pathophysiology of acute pancreatitis［J］.Hepatogastroenterology，1993,40(6):517-21.
［8］Hajnády Z,NagyPénzes M,Demény MA,et al.OGG1 inhibition reduces acinar cell injury in a mouse model of acute pancreatitis［J］.Biomedicines,2022,10(10):2543.
［9］Pandol SJ,Gottlieb RA.Calcium,mitochondria and the initiation of acute pancreatitis［J］.Pancreatology,2022,22(7):838-845.
［10］陈婧华,陈垦,王晖.急性胰腺炎发病机制研究进展［J］.世界华人消化杂志,2009,17(24):2478-2483.
［11］侯俊明,王建华.攻下法在重症急性胰腺炎治疗中的临床作用［J］.现代中医药，2010,30(6):29-30.
［12］Singh N,Sonika U,Moka P,et al.Association of endotoxaemia & gut permeability with complications of acute pancreatitis:Secondary analysis of data［J］.Indian J Med Res，2019,149(6):763-770.
［13］NormanJG,Fink GW,Denham W,et al.Tissuespecific cytokine production during experimental acute pancreatitis.A probable mechanism for distant organ dysfunction［J］.Digestive Diseases and Sciences,1997,42(8):1783-1788.
［14］孔婧,王晓素,姜清宇,等.清下化瘀方对急性胰腺炎胃肠道及免疫功能的保护作用［J］.中国中西医结合消化杂志,2014,22(5):245-248,252.
［15］Riedel S,Melendez JH,An AT,et al.Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department［J］.American Journal of Clinical Pathology,2011,135(2):182-189.
［16］GurdaDuda A,Ku s＇nierzCabala B,Nowak W,et al.Assessment of the prognostic value of certain acutephase proteins and procalcitonin in the prognosis of acute pancreatitis［J］.Pancreas,2008,37(4):449-453.
［17］Bulbuller N.Dogru O,Ayten R,et al.Procalcitonin is a predictive marker for severe acute pancreatitis［J］.Ulus Travma Acil Cerrahi Derg,2006,12(2):115-120.
［18］Kolber W,Dumnicka P,Maraj M,et al.Does the automatic measurement of interleukin 6 allow for prediction of complications during the first 48 h of acute pancreatitis?［J］.International Journal of Molecular Sciences,2018,19(6):1820.
［19］Staubli SM,Oertli D,Nebiker CA.Laboratory markers predicting severity of acute pancreatitis［J］.Critical Reviews in Clinical Laboratory Sciences,2015,52(6):273-283.
［20］Hirano T.IL6 ininflammation,autoimmunity and cancer［J］.International Immunology,2021,33(3):127-148.
［21］Vasseur P,Devaure I,Sellier J,et al.High plasma levels of the proinflammatory cytokine IL-22 and the antiinflammatory cytokines IL-10 and IL1ra in acute pancreatitis［J］.Pancreatology,2014,14(6):465-469.
［22］Tran TH,Rastogi R,Shelke J,et al.Modulation of macrophage functional polarity towards antiinflammatory phenotype with plasmid DNA delivery in CD44 targeting hyaluronic acid nanoparticles［J］.Scientific Reports,2015,5:16632.
［23］Yang XM,Yao LB,Fu XH,et al.Experimental acute pancreatitis models:history,current status,and role in translational research［J］.Frontiers in Physiology,2020,11:614591.
［24］Zhang FH,Sun YH,Fan KL,et al.Protective effects of heme oxygenase-1 against severe acute pancreatitis via inhibition of tumor necrosis factor-α and augmentation of interleukin-10［J］.BMC Gastroenterology,2017,17(1):100.

Memo

基金项目：国家自然科学基金委员会青年项目（82004264）；上海市申康医院发展中心中西医临床协作试点建设项目（ZY2018-2020-FWTX-1004）

Last Update: 2023-09-22