[1] ZHANG HuiWANG Laifa WANG Xueqin DENG Ling CUI Yanhui,.Research Progress on the Antidepressant Mechanism of Zhimu and Its Active Ingredients [J]. Modern Traditional Chinese Medicine, 2023, (06): 1-7. [doi: 10.13424/j.cnki.mtcm.2023.06.001]
Research Progress on the Antidepressant Mechanism of Zhimu and Its Active Ingredients
- Article number:
- 1672-0571(2023)06-0001-07
- Keywords:
- Key words:Zhimu; Active ingredients; Anti depression; Mechanism of action; Research progress
- ZTFLH:
- R285.5
- Code:
- A
- Abstract:
- Abstract：The pathogenesis of depression is complex.Currently, antidepressants can effectively alleviate symptoms.But it cannot be eradicated, and long-term use may lead to some side effects and dependence.The traditional Chinese medicine Zhimu has been used for the treatment of depression for a long time. With the deepening of research, the active components of Zhimu, including total saponins of Zhimu, saponins B-Ⅱ, saponins B-Ⅲ, saponins from Zhimu, diosgenins, saponins from Zhimu, and saponins B-Ⅲ from Zhimu have been identified and developed. The role of Zhimu has the characteristics of multiple targets and pathways, involving mechanisms such as anti neuroinflammation, antioxidant stress, and regulation of neurotransmitter function, demonstrating good potential in the treatment of depression. The article will provide a review of the research progress on the antidepressant mechanisms of Zhimu and its active ingredients, in order to provide reference for researchers to further explore the antidepressant effects of Zhimu.
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Memo
基金项目：湖南省教育厅科研基金项目（22C0673）；湖南省自然科学基金项目（2023JJ30092，2021JJ40644）；长沙医学院2022年第一批ESI学科建设专项课题（2022CYY013）