[1] TIAN Shen, LI Qing, WANG Xiao, et al. A Study on the Serum Neurocytokines，Oxidative Stress，and Hemorheology of Ischemic Stroke Hemiplegia Patients treatedwith Huatan Quyu Decoction and Rehabilitation Therapy [J]. Modern Traditional Chinese Medicine, 2024, (01): 62-67. [doi: 10.13424/j.cnki.mtcm.2024.01.014]
A Study on the Serum Neurocytokines，Oxidative Stress，and Hemorheology of Ischemic Stroke Hemiplegia Patients treatedwith Huatan Quyu Decoction and Rehabilitation Therapy
- Article number:
- 1672-0571(2024)01-0062-06
- Keywords:
- Key words:Huatan Quyu decoction; Ischemic stroke; Hemiplegia; Rehabilitation therapy; Neurocytokines; Oxidative stress; Hemorheology
- ZTFLH:
- R255.2
- Code:
- A
- Abstract:
- Abstract：Objective To analyze the effects of Huatan Quyu decoction combined with conventional rehabilitation treatment on serum neurocytokines，oxidative stress，and hemorheology in patients with hemiplegia after ischemic stroke.Methods Ninety patients with post-stroke hemiplegia who underwent treatment in our hospital from October 2020 to October 2022 were randomly divided into a treatment group (45 cases，treated with Huatan Quyu decoction+conventional rehabilitation treatment) and a control group (45 cases，treated with conventional rehabilitation treatment).Evaluate rehabilitation efficacy，compare limb function，hemorheology，serum oxidative stress indicators，and neurocytokine levels between groups before and after treatment.Results The total effective rate of rehabilitation in the treatment group was significantly higher than that in the control group (P＜0.05)；After treatment，the Fugl Meyer Motor Function Assessment (FMA) scores of the upper and lower limbs in the treatment group were significantly higher than those in the control group (P＜0.05)；After treatment，the whole blood high shear and low shear viscosity in the treatment group were significantly lower than those in the control group (P＜0.05)；After treatment，the serum malondialdehyde (MDA) level in the treatment group was lower than that in the control group，and the superoxide dismutase (SOD) was higher than that in the control group (P＜0.05)；After treatment，the serum levels of matrix metalloproteinase-9 (MMP-9) in the treatment group were significantly lower than those in the control group，and the levels of angiopoietin-1 (Ang-1) were significantly higher than those in the control group (P＜0.05)；After treatment，the levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the treatment group were significantly higher than those in the control group (P＜0.05).Conclusion The combination of Huatan Quyu decoction and conventional rehabilitation therapy has a significant therapeutic effect on hemiplegia patients after ischemic stroke，which can effectively restore limb function.The effective mechanism may be related to improving the patients hemorheology，reducing oxidative stress response，regulating MMP-9 and Ang-1 levels，and increasing the level of neurocytokines.
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Memo
基金项目：陕西省创新能力支撑计划（2017KCT-26）；陕西省教育厅重点科学研究计划项目（20js037；20js038）