[1] HUI Pengli, ZHU SheJiao, WANG Cheng, et al. Exploring the Feasibility of Gegen Qinlian Decoction in Treating Ulcerative Colitis Based on Bioinformatics [J]. Modern Traditional Chinese Medicine, 2024, (01): 95-101. [doi: 10.13424/j.cnki.mtcm.2024.01.020]
Exploring the Feasibility of Gegen Qinlian Decoction in Treating Ulcerative Colitis Based on Bioinformatics
- Article number:
- 1672-0571(2024)01-0095-07
- Keywords:
- Key words:Gegen Qinlian decoction; Damp heat syndrome; Ulcerative colitis; Traditional Chinese medicine; Network pharmacology; Mechanism of action
- ZTFLH:
- R285.5
- Code:
- A
- Abstract:
- Abstract：Objective Based on bioinformatics，to explore the target and mechanism of action of Gegen Qinlian decoction (GGQL) in the treatment of ulcerative colitis (UC).Methods Retrieve the TCMSP database to obtain the effective ingredients and target genes of each drug in the formula；Retrieve the OMIM database and DisGeNET database to obtain disease genes，and intersect drug genes with disease genes to obtain core genes；Then，a gene function association network was constructed using the STRING database；Finally，the DAVID database was used for GO enrichment analysis and pathway enrichment analysis.Results As a result，a total of 278 effective ingredients，410 targets，and 914 disease genes were obtained；A total of 113 core genes were obtained by intersecting drug genes with disease genes.Then，a gene functional association network was constructed using the STRING database.The network information data was imported into Cytoscape software for topology analysis，and it was found that IL6，STAT3，IL1B，VEGFA，MAPK1，EGF，PTGS2，EGFR，ICAM1，MMP9 and other target values were high，which may be core targets；Using the DAVID database for GO enrichment analysis of targets，a total of 16 enriched biological process clusters were obtained，and 26 enriched pathway clusters were obtained through pathway enrichment analysis.Among them，the pathways closely related to inflammation and closely related to targets include the TNF signaling pathway and inflammatory bowel disease signaling pathway.Conclusion The preliminary study has identified the target and pathway of GGQL in the treatment of UC，and combined with relevant published studies，it is believed that GGQL may play a role through the TNF signaling pathway.
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Memo
基金项目：陕西省科技厅项目（2019SF-099