[1] Qin Yao Huang Chonggang Mo Zongcheng Wang Xin Wang Min Huang Wentao Luo Weizao,.Activity Study on Anti － osteoporosis Model with Different Proportions of Epimedium，Fructus Cnidii and Dipsacus Asper Extracts [J]. Modern Traditional Chinese Medicine, 2017, (06): 122-125128. [doi: 10.13424/j.cnki.mtcm.2017.06.043]
Activity Study on Anti － osteoporosis Model with Different Proportions of Epimedium，Fructus Cnidii and Dipsacus Asper Extracts
- Article number:
- 1672-0571(2017)06-0122-05
- Keywords:
- osteoporosis; epimedium; fructus cnidii; dipsacus asper; compound; compatibility
- ZTFLH:
- Ｒ68
- Code:
- A
- Abstract:
- Objective To filtrate the optimal - ratio prescription with good Anti - osteoporosis activity from different proportions of epimedium,fructus cnidii and dipsacus asper extracts by the use of rat osteoporosis model.?Method The rat osteoporosis model was established by retinoic acid,different prescriptions with different proportions of epimedium, fructus cnidii and dipsacus asper extracts were composed,and effects of different proportions of the compound on biochem- ical indexes such as P,Ca,ALP and Sta ACP in the rat s serum as well as femoral bone quality were investigated.?Result Different proportions of the compound with epimedium,fructus cnidii and dipsacus asper extracts all had certain anti-os-teoporosis activity for osteoporotic rat，when it was 2: 1: 1，the anti－osteoporosis activity was the most significant． Conclusion the compound of epimedium，fructus cnidii and dipsacus asper extracts with a 2: 1: 1 compatibility is expected to be a new medicine for the treatment of osteoporosis．
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Memo
收稿日期:2016－12－02编辑:文颖娟
基金项目:重庆市应用开发重大项目(cstc2014yykfC10001);重庆市卫生局重点项目(ZY20131011);国家重大新药创制重庆市创新药物孵化基地项目(2010ZX09401-306-3-8);重庆市自然科学基金重点项目(CSTC2009BA5079)作者简介:覃瑶(1982-),副研究员,博士,主要从事新药筛选研究E-mail:trowa1982@126.com
通讯作者:罗维早(1962-),研究员,博士,博士生导师,主要从事中药