[1] Chen Xiaoqun Jia Gang,.Clinical Study on Qingre Yishen Decoction Combined with Valsartan in Treating Early Renal Damage of Hypertension [J]. Modern Traditional Chinese Medicine, 2019, (04): 50-53. [doi: 10.13424/j.cnki.mtcm.2019.04.015]
Clinical Study on Qingre Yishen Decoction Combined with Valsartan in Treating Early Renal Damage of Hypertension
- Article number:
- 1672 -0571( 2019) 04 -0050 -04
- Keywords:
- early renal damage of hypertension; Qingre Yinshen Decoction; valsartan; renal artery; renal function
- ZTFLH:
- R544.1
- Code:
- B
- Abstract:
- To investigate the effects of Qingre Yishen Decoction combined with valsartan on renal artery hemodynamics and renal function in patients with early renal damage of hypertension. Methods: 220 patients with hypertensive early renal damage admitted to our hospital from December 2017 to December 2018 were randomly divided into control group and treatment group. All patients were treated with valsartan capsule, while patients in treatment group were treated with Qingre Yishen Decoction on this basis. Both groups were treated continuously for 12 weeks. The changes of renal function indexes and renal artery hemodynamics were observed before and after treatment, and the incidence of adverse reactions and clinical efficacy were compared between the two groups. Results: There was no significant difference inrenal artery hemodynamic indexes between the two groups before treatment ( all P > 0. 05) ; after treatment, the renal artery hemodynamic indexes of the two groups were significantly better than those of the group before treatment ( all P < 0.05) ; after treatment, the renal artery hemodynamic indexes of the treatment group were significantly better than those of the control group at the same time. There was no significant difference in renal function indexes between the two groups before treatment ( all P > 0. 05) ; after treatment, the renal function indexes of the two groups were significantly better than those before treatment ( all P < 0. 05) , and the renal function indexes of the treatment group were significantly better than those of the control group after treatment ( all P < 0. 05) . No adverse reactions such as joint pain and dizziness occurred in the two groups during the treatment period. The total effective rate of the treatment group was 91. 82%, which was significantly higher than that of the control group ( 73. 64% ( x 2 = 9. 273, P < 0. 05) . Conclusion: Valsartan capsule combined with Qingre Yishen Decoction can effectively promote the recovery of renal function index and improve the renal artery blood flow in patients with early renal damage of hypertension. It has high safety and remarkable effect? and is worthy of clinical promotion.
References:
[1]周懿明,李浩华,徐婧,等.自拟清热益肾汤联合缬沙坦治疗高血压早期肾损害疗效观察[J].现代中西医结合杂志,2018,27(10):1070-1072.
[2]DoganB,Ak,danM,ErolMK,etal.Opticalcoherencetomographyangiographyfindingsinmalignanthypertensiveretinopathy[J].ArqBrasOftalmol,2019,82(1):72-77.
[3]席管劳.补肾降压汤治疗老年高血压眩晕48例[J].现代中医药,2012,32(2):13-14.
[4]ZhengW,MuJ,ChuC,etal.AssociationofBloodPressureTrajectoriesinEarlyLifewithSubclinicalRenalDamageinMiddleAge[J].JAmSocNephrol,2018,29(12):2835-2846.
[5]ThakurV,ChattopadhyayM.EarlyUrinaryMarkersforDiabeticandOtherKidneyDiseases[J].CurrDrugTargets,2018,19(7):825-831.
[6]钱雷,徐天舒.自拟杞菊地黄汤辅治高血压早期肾损害疗效观察[J].现代中西医结合杂志,2016,25(17):1855-1858.
[7]帅凤俊,王道成,薛刚,等.中西医结合治疗高血压早期肾损害伴颈动脉粥样硬化的临床研究[J].江苏中医药,2017,49(11):28-30.
[8]Lopez-SanzL,BernalS,RecioC,etal.SOCS1-targetedtherapyamelioratesrenalandvascularoxidativestressindiabetesviaSTAT1andPI3Kinhibition[J].LabInvest,2018,98(10):1276-1290.
[9]李杨春,杨长峰.超声心动图检查联合多项检测对高血压早期肾损害的诊断价值[J].中国基层医药,2018,25(6):787-789.
[10]宋晓龙,宋俊,潘仁友,等.通补兼施法治疗高血压早期肾损害疗效观察[J].中国中医急症,2016,25(1):150-152.
[11]胡强,李鹏.中西医结合治疗冠心病合并高血压的疗效及对心功能的影响[J].陕西中医,2016,37(1):27-28.
[12]ShobhaV,FathimaS,PrakashR.Granulomatosiswithpolyangiitis:clinicalcourseandoutcomeof60patientsfromasinglecenterinSouthIndia[J].ClinExpMed,2018,18(3):347-353.
[13]李文华,储珏,沈文博,等.中药药枕在社区高血压病防治中的疗效研究[J].现代中医药,2012,32(2):21-23.
[14]刘海军.高血压中医证型分布特点与心血管危险因素相关性分析[J].陕西中医,2016,37(12):1576-1577.
[15]ThomasG,DrawzPE.BPMeasurementTechniques:WhatTheyMeanforPatientswithKidneyDisease[J].ClinJAmSocNephrol,2018,13(7):1124-1131.
[16]KimD,ShimCY,HongGR,etal.ImpactofAmbulatoryBloodPressureonEarlyCardiacandRenalDysfunctioninHypertensivePatientswithoutClinicallyApparentTargetOrganDamage[J].YonseiMedJ,2018,59(2):265-272.
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收稿日期：２０１８－１０－１２ 编辑：巩振东