[1] Qu Jie, Li Xiaohui, Tan Yingying, et al. Effect of Toxicity and Blood Stasis Removing Recipe on TLR4 and NF - κ B in Rats with Ulcerative Colitis [J]. Modern Traditional Chinese Medicine, 2020, (01): 24-26,32. [doi: 10.13424/j.cnki.mtcm.2020.01.006]
Effect of Toxicity and Blood Stasis Removing Recipe on TLR4 and NF - κ B in Rats with Ulcerative Colitis
- Article number:
- 1672-0571(2020)01-0024-04
- Keywords:
- Toxicity and Blood Stasis Removing Recipe; ulcerative colitis; NF - κ B; Toll - like receptor
- ZTFLH:
- R573.1
- Code:
- A
- Abstract:
- Objective To explore the mechanism of the treatment of ulcerative colitis(UC) by observing the effect of Toxicity and Blood Stasis Removing Recipe on the expression of TLR4 and NF - κ B in the colonic tissue of UC rats. Methods Rat models of ulcerative colitis were replicated using TNBS / ethanol and randomly divided into blank group, model group, Western medicine group, high - dose Chinese medicine group, medium - dose Chinese medicine group, and low - dose Chinese medicine group. After two weeks of treatment, the expression of TLR4 and NF - κB in colon tissue of rats was determined by immunohistochemistry. Results Compared with the blank group, the expression of LR4 and NF - κB were increased in the model group (P < 0. 01); compared with the model group, the expression of LR4 and NF- κB was reduced in each treatment group, especially in the Western medicine group and the high - dose Chinese medicine group (P < 0. 05). Conclusion Toxicity and Blood Stasis Removing Recipe may exert an anti - inflammatory effect by reducing the expression of TLR4 and NF - κB.
References:
[1]屈杰,谭万初,徐春霞,等.从湿热夹瘀论治溃疡性结肠炎急性发作期治疗 [J].四川中医,2014,5(32):32-33.
[2]中华医学会消化病学分会炎症性肠病协作组.对我国炎症性肠病诊断治疗规范的共识意见[J].胃肠病学.2007,12(8):488-495.
[3]屈杰,赵天才.中医药治疗溃疡性结肠炎研究概况[J].中国民族民间医药,2018,27(8):48-51.
[4]于振海,陈立东,王志强,等.Toll样受体 4?NF-κB在溃疡性结肠炎中的表达[J].细胞与分子免疫学杂志,2010,26(7):650-652.
[5]戴路明,朱磊,沈洪.基于 β_2AR/β-arrestin2/NF-κB信号通路的清肠化湿颗粒防治溃疡性结肠炎的作用机制[J].中国实验方剂学杂志,2018,24(9):86-94.
[6]朱磊,沈洪,顾培青,等.黄芩苷对溃疡性结肠炎模型大鼠炎性反应?凋亡的影响及与 PI3K/AKT通路的关系[J].中华中医药杂志,2017,32(9):4001-4004.
[7]彭艳红.溃疡性结肠炎中医病名源流探析[J].辽宁中医药大学学报,2014,16(3):138-139.
[8]李春雷,陈治水.陈治水教授治疗溃疡性结肠炎临床经验[J].中国中西医结合杂志,2008,16(2):112-114.
[9]徐艺.单兆伟论治缓解期溃疡性结肠炎的经验总结[J].辽宁中医杂志,2015,42(12):2311-2312.
[10]屈杰,孔文霞,李培.李培治疗溃疡性结肠炎学术经验总结[J].辽宁中医杂志,2018,45(9):1821-1824.
Memo
基金项目：陕西中医药大学科学研究计划项目（２０１７ＰＹ２３）