[1] Liu Yingxuan Li Zinan,.Treatment of Viral Myocarditis of Acute CVI Children by Huangqi Granules [J]. Modern Traditional Chinese Medicine, 2017, (03): 17. [doi: 10.13424/j.cnki.mtcm.2017.03.007]
Treatment of Viral Myocarditis of Acute CVI Children by Huangqi Granules
- Article number:
- 1672－0571(2017)03－0017－02
- Keywords:
- children; acute CVI ; viral myocarditis; Th1 /Th2 imbalance; Huangqi Granules
- ZTFLH:
- Ｒ37
- Code:
- A
- Abstract:
- Objective: To investigate the effect of Huangqi Granules on viral myocarditis children of acute coxsackie virus infection ( CVI) at infected stage，in which the mechanism of Th1 /Th2 imbalance was explored． Method: The first experimental group was randomly arranged in acute CVI children with viral myocarditis; the second one was added the treatment of Huangqi Granules to the ill children; the third one was the normal control group． To determine the level of serum IFN － γ，IL － 4，cTnI，cTnT and examine children’s ECG were to indirectly understand the condition of Th1 /Th2 imbalance and impairment of heart muscles． Finally，improvements in recovering Th1 /Th2 balance and curative rate of myocarditis after treating by Huangqi Granules could be observed． Ｒesults: Before treatment，serum IFN － γlevels in the first and second group were lower than that in control group ( P ＜ 0． 05) ，IL － 4 levels higher than control group ( P ＜ 0． 05) ，and immunodominance tended to be Th2; after treated by Huangqi Granules，the second group showed that serum IFN － γlevels rose and IL － 4 levels decreased to the levels of the control group ( P ＞ 0． 05) and meanwhile Th1 /Th2 re- covered the balance; elimination coefficient of the abnormal ECG and negative － positive converting rate of cTnI and cTnT in the second group were higher than those in the first group( P ＜ 0． 01) ． Conclusion: The imbalance of Th1 /Th2 is the cause of this kind of myocarditis and the regulating effect of Huangqi Granules is great in increase its curative rate．
References:
[1]潘晓波，孙景辉，高齐． 儿童病毒性心肌炎诊疗进展
［J]． 中国实验诊断学，2014，18( 5) : 863 － 867．
[2]Elliott P，Anderson B，Arbustini E，et al． Classification of the cardiomyopathies: a position statement from the Eu- ropean Society of Cardiology Working Group on myocardial and pericardial diseases［J]． Eur Heart J，2008，29( 2) :
270 － 276．
[3]Chen ＲF，Yeh WT，Yang MY，et al． A model of the real time correlation of viral titers with immune reactions in an- tibody dependent enhancement of dengue － 2 infections ［J]． FEMS Immunol Med Microbiol，2001，30: 17．
[4]颜培宇，于晓红，张德山，等． 黄芪总黄酮对免疫功能
低下小鼠 T 细胞极化的影响［J]． 浙江中医药大学学
报，2008，32( 2) : 163 － 164．
[5]安欣，李惠萍，王归圣． 黄芪注射液联合清开灵注射液
治疗急性病毒性心肌炎疗效观察［J]． 现代中医药， 2007，27( 6) : 19 － 20．
Memo
收稿日期:2016－11－23编辑:杨芳艳