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[1] Guo Jianping, Xia Qin, Dun Wenliang, et al. A Study on the Effect and Mechanism of Huaihua Powder in the Treatment of Ulcerative Colitis by Emulating the Intestinal Subwind Blood Syndrome [J]. Modern Traditional Chinese Medicine, 2020, (05): 9-14/21. [doi: 10.13424/j.cnki.mtcm.2020.05.003]

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A Study on the Effect and Mechanism of Huaihua Powder in the Treatment of Ulcerative Colitis by Emulating the Intestinal Subwind Blood Syndrome

Modern Traditional Chinese Medicine[ISSN: 1006-6977/ CN: 61-1281/TN] Volumes & Issues: 2020 05 pagination: 9-14/21 Column: Publication date: 2023-11-20

Article number:: 1672-0571(2020)05-0009-07

Author(s):: Guo Jianping; Xia Qin; Dun Wenliang; Wu Kunlan; Huang Shuliang; 1.Department of Pharmacy in Nanjing Hospital of Traditional Chinese Medicine, Nanjing Jiangsu 210001;
2.Department of Proctology in Nanjing Hospital of Traditional Chinese Medicine, Nanjing Jiangsu 210001;
3.Department of pathology in Nanjing Hospital of Traditional Chinese Medicine, Nanjing Jiangsu 210001

Keywords:: intestinal subwind blood syndrome; Huaihua powder; ulcerative colitis; TNF - α; MPO

ZTFLH:: R574.62

DOI:: 10.13424/j.cnki.mtcm.2020.05.003

Code:: A

Abstract:: Objective A rat model of ulcerative colitis is established for the study of Huaihua powder ( sophora japonica) in the treatment of intestinal subwind blood syndrome to preliminarily reveal its mechanism. Methods HPLC( high performance liquid chromatography) is used to quantify the Huaihua powder decoction and the extracted parts from rutin, quercetin, naringin and neohesperidin by ethyl acetate and control its quality. In addition, UC rat model is established by 5% of dextran sodium sulfate and evaluate the the therapeutic effect of each part with DAI scores, inflammatory factors and nflammatory cell infiltration. Result The levels of tumor necrosis factor ( TNF - α) and medullary peroxidase ( MPO) inflammatory factors in serum are significantly reduced in the decoction, ethyl acetate and water layer and the DAI score is significantly reduced. The results of tissue sections indicate that the drug could relieve inflammatory cell infiltration, and the anti - inflammatory, anti - ulcer and hemostatic effects become the strongest combining with the decoction. Conclusion The classical prescription of Huaihua powder can effectively treat the rats with ulcerative colitis by reducing the infiltration of inflammatory cells and the level of inflammation. The rat model of ulcerative colitis may also be used as a model of subintestinal wind blood syndrome for the further development of relevant classic prescriptions.

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基金项目：江苏省协同创新项目（Ｈ１４０２）

Last Update: 2020-09-17