[1] Liu Pei, Li Shunan, Fu Meilin, et al. A Study on the Effect of Sanxue Mingmu Tablet Combined with Compaccip on Electroretinogram Adaptation in Patients with Diabetic Retinopathy Complicated with Vitreous Hemorrhage [J]. Modern Traditional Chinese Medicine, 2020, (05): 53-58. [doi: 10.13424/j.cnki.mtcm.2020.05.014]
A Study on the Effect of Sanxue Mingmu Tablet Combined with Compaccip on Electroretinogram Adaptation in Patients with Diabetic Retinopathy Complicated with Vitreous Hemorrhage
- Article number:
- 1672-0571(2020)05-0053-06
- Keywords:
- Sanxue Mingmu tablet; Promoting blood circulation and benefiting water; Diabetic retinopathy; Vitreous hemorrhage; Compaq Sip; Electroretinogram
- ZTFLH:
- R285.6
- Code:
- A
- Abstract:
- Objective To observe the influence of Sanxue Mingmu Tablet on diabetic retinopathy ( DR) patients with vitreous hemorrhage ( VH) . Methods Sixty patients ( 85 eyes) with DR complicated with VH were divided into two groups by random number table method. 30 patients ( 42 eyes) in the control group received vitrectomy for treatment, 1MO intravitreal injection of Compaccip, and 30 patients ( 43 eyes) in the treatment group were treated by oral administration of Sanxue Mingmu tablets after vitrectomy on the basis of the control group. Several BCVA ( best corrected visual acuity) , electroretinogram ( ERG) , and OCT ( Optical coherence tomography) were observed to test the central macular thickness ( CMT) of the two groups after treatment of 4mo. Result The BCVA of patients in the two groups at different times before and after treatment showed statistically significant difference ( P < 0. 001) ; after treatment, the BCVA of patients in 1mo group showed no statistically significant difference ( P > 0. 05) ; after treatment, the BCVA of patients in 2mo group, 3mo group and 4mo group showed statistically significant difference ( P < 0. 05) . In the two groups before and after treatment in patients with different time, light adaptation of a and b wave amplitude difference had statistical significance ( P < 0. 05) , the two groups before and after treatment in patients with different time light adaptation, the wave of latent difference had statistical significance ( P < 0. 05) . After treatment 3mo and 4mo, compared two groups of patients b wave amplitude of light adaptation, differences were statistically significant ( P < 0. 05) ; There were statistically significant differences in CMT between the two groups at different times before and after treatment ( P < 0. 001) , no statistically significant differences in CMT between the two groups at 1mo after treatment ( P > 0. 05) , and there were statistically significant differences in CMT between the two groups at 2mo, 3mo and 4mo after treatment ( P < 0. 05) . Conclusion Compared with the treatment of diabetic retinopathy complicated by vitreous hematoceles with compaccip alone, Sanxue Mingmu tablet combined with compaccip can better reduce retinal edema, improve visual acuity, and reduce the shock waves of visual acuity A and B, and reduce the latency of CMT, visual acuity A and visual acuity B.
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Memo
基金项目:国家自然科学基金面上资助项目(81804150,81574031);中医药防治五官科疾病湖南省重点实验室建设项目(2017TP1018);国家中医药管理局中医眼科学重点学科建设项目(ZK1801YK015);湖南省研究生科研创新项目(CX2018B497) 通讯作者:彭清华,二级教授?E-mail:pqh410007@126.com