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[1] ZHURuikang, LIJiang, LIWentao, et al. MechanismofQianhuDecoctiononAirwayNeurogenicInflammationinRatswithAcuteBronchitis [J]. Modern Traditional Chinese Medicine, 2021, (03): 39-46. [doi: 10.13424/j.cnki.mtcm.2021.03.009]

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MechanismofQianhuDecoctiononAirwayNeurogenicInflammationinRatswithAcuteBronchitis

Modern Traditional Chinese Medicine[ISSN: 1006-6977/ CN: 61-1281/TN] Volumes & Issues: 2021 03 pagination: 39-46 Column: Publication date: 2021-05-20

Article number:: 1672-0571(2021)03-0039-08

Author(s):: ZHURuikang¹; LIJiang¹; LIWentao¹; YANYanfeng²; 1.NanjingUniversityofTraditionalChineseMedicine,Nanjing210023,China; 2.NanjingIntegratedTraditionalChineseandWesternMedicineHospitalAffiliatedto NanjingUniversityofTraditionalChineseMedicine,Nanjing210014,China

Keywords:: Acutebronchitis; QianhuDecoction; Neurogenicinflammation; SubstanceP; Signalpathway

ZTFLH:: R965

DOI:: 10.13424/j.cnki.mtcm.2021.03.009

Code:: A

Abstract:: Objective:ToexploretheregulatorymechanismofQianhuDecoctiononneurogenicinflammationofbronchitis.Methods:Theratmodelofacutebronchitiswasestablishedbysmoking.Theratswererandomlydividedintocontrolgroup,modelgroup,Jizhisyrupgroup,Huifeininggroup,QianhuDecoctionhigh-doseandlow-dosegroups.ThelevelsofsubstanceP(SP),neurokininA(NKA),neurokininB(NKB),calcitoningene-relatedpeptide(CGRP)andnervegrowthfactor(NGF)inserum,thelevelsofneurogenicinflammatoryfactorsinbronchoalveolarlavagefluid,SPandNGFinlungtissue,SPreceptorneurokininreceptorL(NK-1),capsaicinreceptorsubtype1(VR1)andp38MAPKmRNAandproteinoflungtissueweremeasured.Results:Thelevelsofneurogenicinflammatorysubstancesinthemodelgroupweresignificantlyinreased.QianhuDecoctioncouldsignificantlyinhibitthelevelsofneurogenicinflammatorysubstancesinthemodelrats,andtheinhibitioneffectshadacertaindosecorrelation(p<0.05).ThemRNAandproteinexpressionofNK-1andp38MAPKinlungtissueweresignificantlyincreased,butthemRNAandproteinexpressionofVR1werenotsignificantlyaffected.QianhuDecoctionsignificantlyinhibitedtheexpressionofNK-1andp38MAPK(p<0.05),buthadnosignificanteffectsonthemRNAandproteinexpressionofVR1.Conclusion:Thelevelsofneurogenicinflammatorysubstancesinratswithacutebronchitisaresignificantlyincreased.QianhuDecoctioncanimproveairwayneurogenicinflammation,anditsmechanismisrelatedtotheregulationofNGF/SP/p38MAPKsignalingpathway

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Memo

基金项目：南京市卫生科技发展专项资金资助项目（ＹＫＫ１７１９２、ＹＫＫ１８１７２）

Last Update: 2021-06-08