[1] MAJian, LIUJijun, LIHeng,.ClinicalStudyonTheTreatmentofCervicalSpondyloticRadiculopathywithKidneyDeficiencyandBloodStasisSyndromebyDihuangYinziPlusCervicalTraction [J]. Modern Traditional Chinese Medicine, 2021, (03): 95-100. [doi: 10.13424/j.cnki.mtcm.2021.03.020]
ClinicalStudyonTheTreatmentofCervicalSpondyloticRadiculopathywithKidneyDeficiencyandBloodStasisSyndromebyDihuangYinziPlusCervicalTraction
- Article number:
- 1672-0571(2021)03-0095-06
- Keywords:
- Objective:ToinvestigatethecurativeeffectofDihuangYinzicombinedwithcervicaltractioninthetreatmentofcervicalspondyloticradiculopathywithkidneydeficiencyandbloodstasissyndromeanditsinfluenceonthelevelsofserumpainmediatorsprostaglandinE2(PGE2); nitricoxide(NO)
- ZTFLH:
- R681.5+5
- Code:
- A
- Abstract:
- Objective:ToinvestigatethecurativeeffectofDihuangYinzicombinedwithcervicaltractioninthetreatmentofcervicalspondyloticradiculopathywithkidneydeficiencyandbloodstasissyndromeanditsinfluenceonthelevelsofserumpainmediatorsprostaglandinE2(PGE2),nitricoxide(NO),substanceP(SP)andserotonin(5-HT).Methods:90patientswithcervicalspondyloticradiculopathytreatedinXi’anNinthHospitalfromFebruary2015toFebruary2019wererandomlydividedintocontrolgroupandtreatmentgroup,45casesineachgroup.Thecontrolgroupreceivedcervicaltractiontherapy.ThetreatmentgroupwasgivenDihuangYinzionthebasisofthecontrolgroup.After4weeksofcontinuoustreatment,theclinicalevaluationscaleofcervicalspondylosis(CASCS),symptomsofkidneydeficiencyandbloodstasissyndrome,visualanaloguescale(VAS),cervicaldysfunctionindex(NDI)score,clinicalefficacyandserumlevelsofpainmediatorsPGE2,NO,SPand5-HTwerecomparedbetweenthetwogroups.Results:After4weeksoftreatment,thescoresofsubjectivesymptoms,clinicalsignsandadaptabilityofCASCSinthetreatmentgroupweresignificantlyhigherthanthoseinthecontrolgroup,whilethescoresofsymptomsofkidneydeficiencyandbloodstasis,VASandNDIinthetreatmentgroupweresignificantlylowerthanthoseinthecontrolgroup(p<0.01);thetotaleffectiverateinthetreatmentgroupwas97.77%,whichwassignificantlyhigherthanthatinthecontrolgroup(p<0.05);theserumlevelsofPGE2,NO,SPand5-HTinthetreatmentgroupweresignificantlylowerthanthoseinthecontrolgroup.(p<0.01).Conclusion:DihuangYinzioraladministrationcombinedwithcervicaltractioncansignificantlyimprovetheclinicalsymptoms,TCMsyndromesandclinicalefficacyofpatientswithnerveroottypecervicalspondylosisofkidneydeficiencyandbloodstasissyndrome.Itsefficacymayberelatedtothedown-regulationofserumpainmediatorsPGE2,NO,SPand5-HTlevels
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Memo
基金项目：陕西省重点研发计划项目（２０１７ＳＦ１８０）