[1] WU LeileiZHANG Junzhong,.Study on The Mechanism of Taohong Siwu Decoction in The Treatment of Osteoarthritis Based on Network Pharmacology [J]. Modern Traditional Chinese Medicine, 2021, (05): 24-33. [doi: 10.13424/j.cnki.mtcm.2021.05.005]
Study on The Mechanism of Taohong Siwu Decoction in
The Treatment of Osteoarthritis Based on Network Pharmacology
- Article number:
- 1672-0571(2021)05-0024-10
- ZTFLH:
- R289?
- Code:
- A
- Abstract:
- Objective To analyze the mechanism of Taohong Siwu decoction in the treatment of osteoarthritis (OA) based on network pharmacology.Methods The main components and target information of Peach kernel，Safflower，Ligusticum chuanxiong，Angelica sinensis，Rehmannia glutinosa and Radix paeoniae alba in Taohong Siwu decoction were collected and screened by TCMSP database.The drug-components-target network was constructed by Cytoscape 3.7.2 software；Collect relevant target information of OA through Genecards and TTD database；Analyze common targets and draw Wayne diagram with the help of genomics platform；PPI network was constructed by analyzing protein-protein interaction on STRING platform;Go analysis and KEGG signal pathway enrichment analysis were performed by David database (P＜005).Results 64 main components and 219 targets of Taohong Siwu decoction，1 465 OA related targets and 112 common targets were screened.The potential therapeutic targets were AKT1，TP53，IL6 and TNF；592 go biological processes and 106 KEGG signal enrichment pathways were obtained，mainly involving PI3K/Akt signal pathway，MAPK signal pathway and NF-κB signal pathway，etc.Conclusion This study preliminarily analyzed the multi-component，multi-target and multi-channel treatment of OA with Taohong Siwu decoction by network pharmacological method，so as to provide analytical basis for clinical drug use and development.
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Memo
基金项目：国家自然科学基金项目（81973981）；山东省重点研发项目（2019RKB14090，2018GSF118105）