[1] LI Zhichao?TAN Guoqing?XU Zhanwang?XUE Haipeng,.Study on The Relationship Between Hyperthyroidism and Osteoporosis Based on Bioinformatics [J]. Modern Traditional Chinese Medicine, 2021, (05): 53-58. [doi: 10.13424/j.cnki.mtcm.2021.05.009]
Study on The Relationship Between Hyperthyroidism and
Osteoporosis Based on Bioinformatics
- Article number:
- 1672-0571(2021)05-0053-06
- ZTFLH:
- R581.1?
- Code:
- A
- Abstract:
- Objective To explore the relationship between hyperthyroidism and osteoporosis by bioinformatics related techniques.Methods Relevant genes were screened in the related disease database (Disgenet,TTD,OMIM,Drugbank,Genecards) with osteoporosis and hyperthyroidism as key words，After de integration，the two groups of predicted target genes were mapped to obtain the key targets，the target PPI interaction network was obtained through the STRING website，the core targets were screened according to the degree value，and the go enrichment analysis and KEGG pathway analysis were carried out through the DAVID database.Results 875 and 221 targets related to osteoporosis and hyperthyroidism were screened through the search of related disease database，and 99 key targets were mapped.16 core targets were screened by degree ≥35 and imported into DAVID database.44 go enrichment results (P<0.05) and 45 KEGG signal pathways (P<0.05) were obtained.Conclusion INS，IL6，ALB，TNF，IGF1 and other core targets act on JAK STAT pathway，PI3K-Akt pathway，HIF-1 pathway，cytokine and cytokine receptor interaction pathway，IBD pathway and other signal pathways，and regulate osteoporosis and hyperthyroidism at the same time.Although the two complex metabolic diseases contain many targets，But it is still closely related to the molecular mechanism.Applied bioinformatics has high confidence and reference value，which provides a new direction and new ideas for exploring the relationship between diseases.
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Memo
基金项目：国家自然科学基金项目(81473709)；曹贻训全国名老中医传承工作室建设项目（国中医药人教函\[2018\]134号）；徐展望山东省名老中医药专家传承工作室建设项目(山东省卫生健康委员会，鲁卫函\[2019\]92号)