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基金项目:河北省自然科学基金青年项目(C2019402141);河北省高等学校科学技术研究项目(QN2019215);邯郸市科学技术研究与发展计划项目(1727201061);河北省卫生和计划生育委员会科研基金项目(201909620);邯郸市科技局资助项目(1823208029ZC)