[1] ZHANG Xingxing ZHAO Lu WANG Bin,.Literature Analysis on Mechanism of Cerebral Ischemia-reperfusion Injury and Prevention and Treatment of Traditional Chinese Medicine [J]. Modern Traditional Chinese Medicine, 2022, 1(02): 6-16. [doi: 10.13424/j.cnki.mtcm.2022.02.002]
Literature Analysis on Mechanism of Cerebral Ischemia-reperfusion Injury and Prevention and Treatment of Traditional Chinese Medicine
- Article number:
- 1672-0571(2022)02-0006-11
- Keywords:
- Key words：Ischemic cerebrovascular disease; Cerebral ischemia reperfusion injury; Pathological pathogenesis; Research progress; Traditional Chinese medicine
- ZTFLH:
- R259
- Code:
- A
- Abstract:
- Abstract：Ischemic cerebrovascular disease is a kind of cerebral dysfunction caused by insufficient blood supply in a certain part of the brain，which can be accompanied by cerebral thrombosis and other characteristics.It has the characteristics of high incidence rate，high mortality rate and high disability rate.It has become a hot topic of medical researchers in recent years.However，after the blood and oxygen supply of ischemic brain tissue is restored，it may lead to more serious brain tissue injury，namely cerebral ischemia-reperfusion injury，and its injury mechanism is complex and diverse，mainly including inflammatory reaction，neuronal apoptosis，excitatory amino acid poisoning，free radical and lipid peroxidation，toxic reaction of no，intracellular Ga+ overload and mitochondrial dysfunction，In recent years，traditional Chinese medicine has shown good effects in the treatment of cerebral ischemia-reperfusion injury，but its material basis and mechanism need to be further studied.This paper systematically integrates the research on the pathogenesis of cerebral ischemia-reperfusion injury and the application of traditional Chinese medicine in the treatment of the disease in recent years，in order to provide reference for the clinical research and development of new drugs.
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Memo
基金项目：国家自然科学基金（81473385）；陕西省自然科学基金项目(2018JM7111)；陕西中医药大学学科创新项目（2019-YL13）