[1] CHENG Gong SUN Fenglei Feng Bo,.Relationship Between Spleen Deficiency Damp Heat Syndrome and Intestinal Flora in Early Diabetes [J]. Modern Traditional Chinese Medicine, 2022, 1(04): 6-11. [doi: 10.13424/j.cnki.mtcm.2022.04.002]
Relationship Between Spleen Deficiency Damp Heat
Syndrome and Intestinal Flora in Early Diabetes
- Article number:
- 1672-0571(2022)04-0006-07
- ZTFLH:
- R255.4
- Code:
- A
- Abstract:
- Abstract：The incidence of pre diabetes is very high in incidence rate. The incidence of pre diabetes is the result of the interaction of dietary structure，genetic and social environmental factors. Intestinal flora participates in human energy metabolism. Its composition and metabolic disorder are closely related to insulin resistance and glucose and lipid metabolism. The mechanism of action is mainly related to its metabolites，microorganism gut brain axis and intestinal hormones. Traditional Chinese medicine has achieved good clinical results in the early stage of diabetes by treating the spleen. The intestinal flora is similar to the function of spleen in traditional Chinese medicine. Therefore，by studying the relationship between intestinal flora and spleen deficiency and early stage of diabetes.Based on the theory of damp heat due to spleen deficiency，this paper discusses the mechanism of intestinal flora through its metabolites，neuromodulation and related intestinal hormones in the early stage of diabetes，in order to provide a new idea for the treatment of early stage of diabetes and related metabolic system diseases in traditional Chinese medicine.
References:
［1］中华医学会内分泌学分会,中华医学会糖尿病学分会,中国医师协会内分泌代谢科医师分会,等.中国成人糖尿病前期干预的专家共识［J］.中华内分泌代谢杂志,2020,36(5):371-380.
［2］Yang WY,Lu JM,Weng JP,et al.Prevalence of diabetes among men and women in China［J］.The New England Journal of Medicine,2010,362(12):1090-1101.
［3］Zackular JP,Baxter NT,Iverson KD,et al.The gut microbiome modulates colon tumorigenesis［J］.mBio,2013,4(6):e00692-e00613.
［4］中华中医药学会糖尿病分会.糖尿病前期中医诊疗标准［J］.世界中西医结合杂志,2011,6(5):446-449.
［5］郑静,王刚.胃肠道微生态与中医基础理论［J］.陕西中医学院学报,2007,30(1):10-12.
［6］Kc D,Sumner R,Lippmann S.Gut microbiota and health［J］.Postgraduate Medicine,2020,132(3):274.
［7］Turnbaugh PJ,Ley RE,Hamady M,et al.The human microbiome project［J］.Nature,2007,449(7164):804-810.
［8］Ghaemi F,Fateh A,Sepahy AA,et al.Intestinal microbiota composition in Iranian diabetic,pre-diabetic and healthy individuals［J］.Journal of Diabetes & Metabolic Disorders,2020,19(2):1199-1203.
［9］Ratajczak W,Ry A,Mizerski A,et al.Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)［J］.Acta Biochimica Polonica,2019,66(1):1-12.
［10］Christiansen CB,Gabe MBN,Svendsen B,et al.The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon［J］.American Journal of Physiology Gastrointestinal and Liver Physiology,2018,315(1):G53-G65.
［11］Perry RJ,Peng L,Barry NA,et al.Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome［J］.Nature,2016,534(7606):213-217.
［12］Tilg H,Moschen AR.Microbiota and diabetes:an evolving relationship［J］.Gut,2014,63(9):1513-1521.
［13］Zhou D,Pan Q,Xin FZ,et al.Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier［J］.World Journal of Gastroenterology,2017,23(1):60-75.
［14］Watanabe M,Horai Y,Houten SM,et al.Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure［J］.Journal of Biological Chemistry,2011,286(30):26913-26920.
［15］Sun RB,Yang N,Kong B,et al.Orally administered berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal FXR signaling pathway［J］.Molecular Pharmacology,2017,91(2):110-122.
［16］Holter MM,Chirikjian MK,Govani VN,et al.TGR5 signaling in hepatic metabolic health［J］.Nutrients,2020,12(9):2598.
［17］Frost G,Sleeth ML,Sahuri-Arisoylu M,et al.The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism［J］.Nature Communications,2014,5:3611.
［18］Sun HL,Wang NJ,Cang Z,et al.Modulation of microbiota-gut-brain axis by berberine resulting in improved metabolic status in high-fat diet-fed rats［J］.Obesity Facts,2016,9(6):365-378.
［19］Delzenne NM,Cani PD.Nutritional modulation of gut microbiota in the context of obesity and insulin resistance:potential interest of prebiotics［J］.International Dairy Journal,2010,20(4):277-280.
［20］张琦,赵天才.金匮要略［M］.北京:中国医药科技出版社,2012.
［21］车轶文,于宁,翟双庆.脾与肠道菌群相关性的理论探析［J］.世界中医药,2015,10(5):703-705，709.
［22］杨化冰,邹小娟,孔明望,等.肠道微生态与传统中医思想内涵［J］.中医杂志,2017,58(12):1070-1072.
［23］刘玲,陆西宛,何珂,等.七味白术散对脾虚湿困型肥胖症患者糖脂代谢及肠道菌群的影响［J］.中医杂志,2020,61(23):2082-2086.
［24］闫志强,翟少钦,张邑帆,等.脾虚泄泻大鼠肠道菌群的组成和多样性［J］.湖南农业大学学报(自然科学版),2021,47(5):580-586.
［25］王卓,彭颖,李晓波.四君子汤对两种脾虚模型大鼠肠道菌群紊乱的影响［J］.中国中西医结合杂志,2009,29(9):825-829.
［26］刘凯文.基于高通量测序探讨参苓白术散对脾气亏虚型泄泻肠道菌群的影响［D］.北京：北京中医药大学,2019.
［27］张再康.《脾胃论》入门导读［M］.北京：中国医药科技出版社，2018.
［28］余丽华,李吉武.论“脾主四时”与肠道菌群的相关性［J］.亚太传统医药,2021,17(6):210-213.
［29］姜婷,纪文岩,陆为民.从肠道菌群浅析“脾为之卫”的科学内涵与临床应用［J］.中国中西医结合杂志,2020,40(10):1268-1272.
［30］张隐庵,孙国中,方向红.黄帝内经素问集注［M］.北京：学苑出版社,2002.
［31］白俊杰,翟双庆.日儒森立之著《素问考注》的学术成就［J］.吉林中医药,2010,30(3):265-267.
［32］贺宏波,闫韶哗,杨玲玲,等.5930例2型糖尿病患者舌象与实验室指标相关性分析［J］.中医杂志,2013,54(23):2031-2034.
［33］刘香春,苏文博,蒲蔚荣,等.消渴病湿热致病机理与治法探讨［J］.中国中医基础医学杂志,2016,22(8):1121-1122.
［34］张新霞,刘万富,熊冉,等.参芪复方对初诊2型糖尿病气阴两虚兼血瘀证患者肠道微生态的影响［J］.中国实验方剂学杂志,2019,25(22):72-77.
［35］赵志祥,简小兵,王文英.玉液汤对2型糖尿病肥胖患者肠道菌群及脂质代谢的影响［J］.世界中医药,2020,15(19):2959-2962.
［36］王涵,顾成娟,吴学敏,等.葛根、黄连、黄芩治疗2型糖尿病胃肠湿热证——仝小林三味小方撷萃［J］.吉林中医药,2019,39(12):1569-1572.
［37］潘赏赏,李力,王娴.黄连温胆汤联合盐酸二甲双胍对湿热内蕴型早期2型糖尿病患者的临床疗效［J］.中成药,2021,43(2):557-559.
［38］Zhang W,Xu JH,Yu T,et al.Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice［J］.Biomedicine & Pharmacotherapy,2019,118:109131.
［39］司原成,苗维纳,何嘉悦,等.基于“脑-肠-菌”轴探讨健脾益气针法对肥胖鼠肠道菌群及TLR4的调控机制［J］.中华中医药杂志,2017,32(10):4457-4460.
［40］宋爱群,张阳普,陈瑞,等.电针对胰岛素抵抗肥胖大鼠肠道菌群的影响［J］.中国中西医结合消化杂志,2020,28(9):656-662.
Memo
基金项目：国家自然科学基金青年基金项目（81704026);山东省自然科学基金项目（ZR2016HB04)