[1] ZHANG Yilu JIAO Lijing XU Ling,.Retrospective Analysis of Effect of Integrated Traditional Chinese and Western Medicine on Survival and Prognosis of 951 Patients with Lung Cancer based on Real World [J]. Modern Traditional Chinese Medicine, 2022, 1(04): 119-126. [doi: 10.13424/j.cnki.mtcm.2022.04.023]
Retrospective Analysis of Effect of Integrated Traditional Chinese
and Western Medicine on Survival and Prognosis of 951 Patients
with Lung Cancer based on Real World
- Article number:
- 1672-0571(2022)04-0119-08
- Keywords:
- Key words：Real world; Retrospective analysis; Lung cancer; Integrated traditional Chinese and Western medicine; Survival prognosis
- ZTFLH:
- R273
- Code:
- A
- Abstract:
- Abstract：Objective To retrospectively analyze the effect of integrated traditional Chinese and Western medicine on the survival and prognosis of lung cancer patients. Methods The data of 951 cases of lung cancer treated with combination of Chinese and Western medicine in certain hospital from January 2003 to August 2009 were retrospectively analyzed. The independent prognostic factors affecting survival were analyzed by Kaplan-Meier and Cox regression. Results ① After the treatment with Chinese medicine，the median survival time of 951 patients was 45 months in stage Ⅰ a，44 months in stage Ⅰ b，39 months in stage Ⅱ a，34 months in stage Ⅱ b，19 months in stage Ⅲ a，17 months in stage Ⅲ b and 14 months in stage Ⅳ. ② 1-5 year survival rate: stage I: 77%，66%，56%，51%，12%；stage Ⅱ:67%，57%，49%，39%，18%；stage III: 42%，26%，19%，13%，4%；stage Ⅳ:31%，19%，14%，8%，2%. ③ Univariate analysis showed that gender，age，smoking index，clinical stage，pathological type，syndrome differentiation，treatment principle，duration of traditional Chinese medicine，operation and chemotherapy were the influencing factors of survival and prognosis (P<0.05)；multivariate analysis showed that sex，age，clinical stage，pathological type，treatment principle，duration of taking traditional Chinese medicine，operation and chemotherapy were independent prognostic factors for lung cancer patients (P<0.05).Conclusion There are many factors influencing the prognosis of lung cancer patients treated with integrated traditional Chinese and Western medicine，among which gender，age，clinical stage，pathological type，treatment principle，duration of traditional Chinese medicine，operation and chemotherapy are the main factors affecting the prognosis.Abstract：Objective To retrospectively analyze the effect of integrated traditional Chinese and Western medicine on the survival and prognosis of lung cancer patients. Methods The data of 951 cases of lung cancer treated with combination of Chinese and Western medicine in certain hospital from January 2003 to August 2009 were retrospectively analyzed. The independent prognostic factors affecting survival were analyzed by Kaplan-Meier and Cox regression. Results ① After the treatment with Chinese medicine，the median survival time of 951 patients was 45 months in stage Ⅰ a，44 months in stage Ⅰ b，39 months in stage Ⅱ a，34 months in stage Ⅱ b，19 months in stage Ⅲ a，17 months in stage Ⅲ b and 14 months in stage Ⅳ. ② 1-5 year survival rate: stage I: 77%，66%，56%，51%，12%；stage Ⅱ:67%，57%，49%，39%，18%；stage III: 42%，26%，19%，13%，4%；stage Ⅳ:31%，19%，14%，8%，2%. ③ Univariate analysis showed that gender，age，smoking index，clinical stage，pathological type，syndrome differentiation，treatment principle，duration of traditional Chinese medicine，operation and chemotherapy were the influencing factors of survival and prognosis (P<0.05)；multivariate analysis showed that sex，age，clinical stage，pathological type，treatment principle，duration of taking traditional Chinese medicine，operation and chemotherapy were independent prognostic factors for lung cancer patients (P<0.05).Conclusion There are many factors influencing the prognosis of lung cancer patients treated with integrated traditional Chinese and Western medicine，among which gender，age，clinical stage，pathological type，treatment principle，duration of traditional Chinese medicine，operation and chemotherapy are the main factors affecting the prognosis.
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Memo
基金项目：国家中医药管理局中医药循证能力建设项目(2019XZZX-ZL004)；上海市卫健委中西医临床协作试点项目（ZXYXZ-201901）；虹口区名中医许玲学术经验传承工作室、虹口区名中医许玲北外滩社区工作站、虹口区“国医强优”三年行动计划（2018-2020年）名中医工作室（站）建设项目（HGYMZY-2018-11）；上海市中医诊疗模式创新试点建设项目-肺癌中医诊疗身心全程管理诊疗模式创新试点（ZY(2018-2020)-FWTX-6009）