[1] ZHAO Honggao WANG Jing WANG Penghui FANG Yingying XING Chen XI Dandan,.linical Study on the Efficacy of Modified Banxia Houpu DecoctionCombined with Fluoxetine Hydrochloride in the Treatment of Patients with Coronary Heart Disease and Angina Pectoris and Depression [J]. Modern Traditional Chinese Medicine, 2023, (06): 59-63. [doi: 10.13424/j.cnki.mtcm.2023.06.013]
linical Study on the Efficacy of Modified Banxia Houpu DecoctionCombined with Fluoxetine Hydrochloride in the Treatment of Patients with Coronary Heart Disease and Angina Pectoris and Depression
- Article number:
- 1672-0571(2023)06-0059-05
- Keywords:
- Key words:Banxia Houpu decoction; Fluoxetine hydrochloride; Coronary heart disease and angina pectoris; Depression; Neurotransmitters
- ZTFLH:
- R256.22
- Code:
- A
- Abstract:
- Abstract：Objective To explore the therapeutic effect of modified Banxia Houpu decoction combined with fluoxetine hydrochloride on patients with coronary heart disease angina pectoris and depression.Methods 88 patients with coronary heart disease angina pectoris and depression admitted to our hospital from March 2020 to March 2022 were randomly divided into a treatment group and a control group, with 44 patients in each group receiving conventional Western medicine treatment. The control group received fluoxetine hydrochloride, while the treatment group received fluoxetine hydrochloride combined with modified Banxia Houpu decoction. The clinical efficacy was evaluated, and the incidence of angina pectoris, depression, and anxiety in the two groups of patients before and after treatment were compared, measure the levels of serum neurotransmitters in both groups and record adverse reactions.Results The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05); After treatment, the number of angina attacks, duration, and pain visual analogue scale (VAS) score in the treatment group were significantly lower than those in the control group (P<0.05); After treatment, the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores in the treatment group were significantly lower than those in the control group (P<0.05); After treatment, the serum levels of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) in the treatment group were significantly higher than those in the control group (P<0.05); There was no significant difference in the incidence of adverse reactions between groups (P>0.05). Conclusion The combination of modified Banxia Houpu decoction and fluoxetine hydrochloride can significantly improve the symptoms of angina pectoris and neurotransmitter levels in patients with coronary heart disease and depression, alleviate depression and anxiety, and have high safety.
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Memo
基金项目：宝鸡市卫健委市级科研项目（2019-25）