[1] WANG JingGUO JinyuanYANG HailongLI GangZHANG Yunfeng,.Effect of Yiqi Qiangxin Decoction Combined with Western MedicineComprehensive Treatment on Vascular Endothelial Functionand Cardiac Function in Patients with Chronic Heart Failure [J]. Modern Traditional Chinese Medicine, 2024, (03): 58-62. [doi: 10.13424/j.cnki.mtcm.2024.03.011]
Effect of Yiqi Qiangxin Decoction Combined with Western MedicineComprehensive Treatment on Vascular Endothelial Functionand Cardiac Function in Patients with Chronic Heart Failure
- Article number:
- 1672-0571(2024)03-0058-05
- Keywords:
- Key words:Yiqi Qiangxin decoction; Chronic heart failure; Vascular endothelial function; Heart function; Randomized controlled
- ZTFLH:
- R256.2
- Code:
- A
- Abstract:
- Abstract：Objective To analyze the effect of Yiqi Qiangxin decoction combined with Western medicine comprehensive treatment on the heart function and endothelial function of patients with chronic heart failure.Methods 92 patients with chronic heart failure admitted to Baoji High tech Hospital from March 2020 to May 2022 were randomly divided into a control group (46 cases，Western medicine comprehensive treatment) and a combination treatment group (46 cases，Western medicine comprehensive treatment+Yiqi Qiangxin decoction).The differences in levels of oxidative stress indicators，inflammatory factors，vascular endothelial function indicators，and cardiac function indicators between the groups before and after treatment were measured and compared，and adverse reactions were recorded.Results After treatment，the combined treatment group showed a higher increase in superoxide dismutase (SOD) levels and a greater decrease in malondialdehyde (MDA) levels (P<0.05)；After treatment，the levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were lower in the combined treatment group (P<0.05)；After treatment，the level of endothelin-1 (ET-1) in the combined treatment group was significantly lower than that in the control group，and the level of nitric oxide (NO) was significantly higher than that in the control group (P<0.05)；After treatment，the left ventricular end systolic volume (LVESV) in the combined treatment group was significantly lower than that in the control group，and the left ventricular ejection fraction (LVEF) was significantly higher than that in the control group (P<0.05)；There was no significant difference in the incidence of adverse reactions between the two groups of patients during the administration period (P>0.05).Conclusion The combination of Yiqi Qiangxin decoction and Western medicine comprehensive treatment can improve the inflammatory response and oxidative stress response of patients with chronic heart failure，reduce endothelial damage，restore heart function，and basically do not increase adverse reactions.
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Memo
基金项目：陕西省重点研发计划项目（S2017-ZDYF-YBXM-SF-0221）