[1] ZHENG MeieXIONG YanlingKANG XuruiTANG QunLIAO HaiyanMENG Bin LXiang HUANG Lei,.Role of Caspase-3 Mediated Cell Apoptosis and Cell Pyroptosisin Hepatocellular Carcinoma and Research Progress ofTraditional Chinese Medicine Treatment [J]. Modern Traditional Chinese Medicine, 2024, (04): 1-6. [doi: 10.13424/j.cnki.mtcm.2024.04.001]
Role of Caspase-3 Mediated Cell Apoptosis and Cell Pyroptosisin Hepatocellular Carcinoma and Research Progress ofTraditional Chinese Medicine Treatment
- Article number:
- 1672-0571(2024)04-0001-06
- Keywords:
- Key words:Caspase-3; Cell apoptosis; Cell pyroptosis; Hepatocellular carcinoma; Traditional Chinese medicine
- ZTFLH:
- R273
- Code:
- A
- Abstract:
- Abstract：Apoptosis and cell pyroptosis are two important programmed cell death modes, and cysteine protease-3 (Caspase-3) plays an important role in both of these death modes. It participates in endogenous and exogenous pathways mediated cell apoptosis and Caspase-3/GSDME dependent cell pyroptosis, playing a crucial role in the treatment of hepatocellular carcinoma (HCC). In recent years, there has been a continuous increase in research literature on traditional Chinese medicine for the treatment of hepatocellular carcinoma through Caspase-3 mediated cell apoptosis and cell pyroptosis, which has great potential in providing ideas for the treatment of hepatocellular carcinoma. This article provides a review of the role of Caspase-3 mediated cell apoptosis and pyroptosis in hepatocellular carcinoma, as well as the research achievements in traditional Chinese medicine treatment, in order to provide assistance for the treatment and drug research of hepatocellular carcinoma.
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Memo
基金项目：湖南省自然科学基金项目（2021JJ30506）；湖南省卫生健康委科研重点项目（C202203108338）；湖南中医药大学大学生创新创业训练项目（1008058/9982）；湖南中医药大学重点培育学科基础医学学科资助（校行发规字【2023】2号）