[1] YANG JinghuaWANG LiangZHANG YanWANG Yong GUO Wei,.Textual Research on the Ancient and Modern Efficacy of Mulberry Leaves [J]. Modern Traditional Chinese Medicine, 2024, (04): 83-92. [doi: 10.13424/j.cnki.mtcm.2024.04.017]
Textual Research on the Ancient and Modern Efficacy of Mulberry Leaves
- Article number:
- 1672-0571(2024)04-0087-10
- Keywords:
- Key words:Mulberry leaves; Ancient and modern textual research; Modern research; Clinical application
- ZTFLH:
- R282.71
- Code:
- A
- Abstract:
- Abstract：Through reviewing ancient texts such as traditional Chinese medicine and medical books, combined with modern literature analysis, this paper comprehensively investigates and sorts out the evolution and changes of the efficacy of mulberry leaves, as well as modern basic and clinical research. It also compares and analyzes the historical and modern continuity and application differences of mulberry leaf efficacy. The results indicate that mulberry leaves have a complex range of functions and diverse uses. Their anti cold and hot effects have been recorded since the Han dynasty, and evolved into anti wind and warm effects in the Qing dynasty, which have been used to this day; Mingmu efficacy was proposed in the Han dynasty, developed in ophthalmology during the Tang dynasty, and was reused during the Ming and Qing dynasties. Although modern Mingmu efficacy has been included in the pharmacopoeia, research and application are relatively limited; The anti thirst effect was proposed in the Ming dynasty. Before the Ming dynasty, mulberry leaves were mostly used to quench thirst, which evolved from this. Modern literature analysis shows that mulberry leaves have performed well in the treatment of diabetes in the past 20 years, and the basic research is relatively comprehensive; The anti sweat effect began in the Han dynasty and developed during the Song and Ming dynasties. It was most commonly used in the Qing dynasty but less commonly used in modern times; The hemostatic effect was widely used in the Ming dynasty, and after the innovative treatment of women’s metrorrhagia and leakage in the Qing dynasty, modern medical practitioners also continued to use it, but there are currently few clinical reports; There is little mention of other effects such as treating insect and snake bites, and stopping cholera. Mulberry leaves are abundant in resources, with high medicinal value and health functions, but the current level of development is relatively low. Therefore, based on modern clinical needs, it is recommended to take the historical efficacy of mulberry leaves as the starting point, while paying attention to existing research hotspots, to deeply explore their historical efficacy such as improving eyesight, stopping sweating, and stopping bleeding. The article can provide a basis for the clinical application of mulberry leaves and a reference for the discovery of innovative drugs based on mulberry leaves.
References:
［1］国家药典委员会.中华人民共和国药典［S］.北京:中国医药科技出版社,2020.
［2］翁维良,房书亭.临床中药学［M］.郑州:河南科学技术出版社,1998.
［3］GAO XH,ZHANG SD,WANG LT,et al.Anti-inflammatory effects of neochlorogenic acid extract from mulberry leaf (Morus alba l.) against LPS-stimulated inflammatory response through mediating the AMPK/Nrf2 signaling pathway in A549 cells［J］.Molecules,2020,25(6):1385.
［4］SHIBATA Y,KUME N,ARAI H,et al.Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation and lectin-like oxidized LDL receptor-1 (LOX-1) expression in vascular endothelial cells［J］.Atherosclerosis,2007,193(1):20-27.
［5］侯瑞宏,廖森泰,刘凡,等.桑叶多糖对小鼠免疫调节作用的影响［J］.食品科学,2011,32(13):280-283.
［6］秦雪娟,马成.桑叶与菊花配伍退热机制实验研究［J］.新中医,2013,45(11):133-135.
［7］国家药典委员会.中华人民共和国药典［S］.一部. 北京:化学工业出版社,2005.
［8］中央人民政府卫生部.中华人民共和国药典［S］.上海:商务印书馆,1953.
［9］中国医学科学院陕西分院中医研究所.陕西中药志(第一册)［M］.西安:陕西人民出版社,1962.
［10］ 国家中医药管理局.中华本草［M］.上海:上海科学技术出版社,2005.
［11］肖培根,连文琰.中药植物原色图鉴［M］.北京:中国农业出版社,1999.
［12］肖培根.新编中药志(第三卷)［M］.北京:化学工业出版社,2002.
［13］叶定江,原思通.中药炮制学辞典［M］.上海:上海科学技术出版社,2005.
［14］路军章,韦桂宁.实用本草纲目彩色图鉴［M］.北京:中医古籍出版社,2013.
［15］冉先德.中华药海:精华本［M］.北京:东方出版社,2010.
［16］吕景山.施今墨对药［M］.北京:人民军医出版社,1996.
［17］CHAN EWC,LYE PY,WONG SK.Phytochemistry,pharmacology,and clinical trials of Morus alba［J］.Chinese Journal of Natural Medicines,2016,14(1):17-30.
［18］鱼晓敏,安馨,鲁慧,等.桑叶水提物与醇提物对糖尿病小鼠的协同降血糖效应［J］.卫生研究,2018,47(3):432-436.
［19］JUNG SH,HAN JH,PARK HS,et al.Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals［J］.BMC Complementary and Alternative Medicine,2019,19(1):55.
［20］GE Q,CHEN L,TANG M,et al.Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology［J］.European Journal of Pharmacology,2018,833:50-62.
［21］LI Q,WANG C,LIU F,et al.Mulberry leaf polyphenols attenuated postprandial glucose absorption via inhibition of disaccharidases activity and glucose transport in Caco-2 cells［J］.Food & Function,2020,11(2):1835-1844.
［22］MENG QH,QI X,FU Y,et al.Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes［J］.Journal of Ethnopharmacology,2020,248:112326.
［23］NAOWABOOT J,PANNANGPETCH P,KUKONGVIRIYAPAN V,et al.Antihyperglycemic,antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats［J］.Plant Foods for Human Nutrition,2009,64(2):116-121.
［24］NAOWABOOT J,CHUNG CH,PANNANGPETCH P,et al.Mulberry leaf extract increases adiponectin in murine 3T3-L1 adipocytes［J］.Nutrition Research,2012,32(1):39-44.
［25］LIU CG,MA YP,ZHANG XJ.Effects of mulberry leaf polysaccharide on oxidative stress inpancreatic β-cells of type 2 diabetic rats［J］.European Review for Medical and Pharmacological Sciences,2017,21(10):2482-2488.
［26］TIAN SM,WANG M,LIU CY,et al.Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway［J］.BMC Complementary and Alternative Medicine,2019,19(1):326.
［27］ZHANG LW,SU SL，DAI XX,et al.Regulatory effect of mulberry leaf components on intestinal microflora in db/db mice［J］.Acta Pharmaceutica Sinica,2019.
［28］LI YZ,ZHANG XP,LIANG CL,et al.Safety evaluation of mulberry leaf extract:acute,subacute toxicity and genotoxicity studies［J］.Regulatory Toxicology and Pharmacology,2018,95:220-226.
［29］RICHE DM,RICHE KD,EAST HE,et al.Impact of mulberry leaf extract on type 2 diabetes (Mul-DM):a randomized,placebo-controlled pilot study［J］.Complementary Therapies in Medicine,2017,32:105-108.
［30］JZEFCZUK J,MALIKOWSKA K,GLAPA A,et al.Mulberry leaf extract decreases digestion and absorption of starch in healthy subjects—a randomized,placebo-controlled,crossover study［J］.Advances in Medical Sciences,2017,62(2):302-306.
［31］WANG RH,LI YF,MU W,et al.Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates［J］.Medicine,2018,97(34):e11996.
［32］王涵,顾成娟,仝小林.桑叶、桑枝、桑白皮治疗糖尿病经验:仝小林三味小方撷萃［J］.吉林中医药,2019,39(11):1463-1465.
［33］史银春,傅强,王世东,等.国医大师吕仁和应用桑科植物治疗糖尿病及并发症临床经验［J］.海南医学院学报,2021,27(13):1028-1031.
［34］杜武勋,田凤英.桑叶止汗考［J］.天津中医学院学报,1997,16(1):8.
［35］覃文慧.桑叶止汗功效初探［J］.四川中医,2011,29(8):52-53.
［36］梁亚平,宁万金,徐卫兰.桑叶治疗汗证的应用总结［J］.中医临床研究,2019,11(30):128-129.
［37］张安富,杨林.50例盗汗症桑叶散治疗疗效分析［J］.中国现代药物应用,2007,1(5):3.
［38］魏华,路洁.浅谈桑叶止汗功效及应用［J］.新中医,2004,36(9):75.
［39］孔雪,张莉,李永攀,等.桑叶炮制历史沿革及国医大师徐经世炒桑叶应用医案举隅［J］.中医药临床杂志,2019,31(10):1820-1822.
［40］徐国钧,何宏贤,徐珞珊,等.中国药材学［M］.北京:中国医药科技出版社,1996.
［41］杨映映,邸莎,李青伟,等.桑叶的配伍经验及用量探究［J］.世界中医药,2019,14(4):1051-1055.
［42］裘笑梅.裘笑梅妇科临床经验选［M］.杭州:浙江科学技术出版社,1982.
［43］陈少春,吕直.何子淮女科经验集［M］.杭州:浙江科学技术出版社,1982.
［44］中华全国中医学会浙江分会,浙江省中医药研究所.医林荟萃［M］.杭州:浙江卫生局,1981.
［45］方鸿浩,游方,韦文双,等.黎烈荣运用桑叶治疗更年期崩漏经验［J］.中国中医基础医学杂志,2016,22(2):259-260.
［46］白华.《神农本草经》桑叶考证［J］.内蒙古中医药,2016,35(1):102-103.
［47］高学敏.中药学［M］.北京:中国中医药出版社，2010.
［48］孙经梦,刘骏,李炯,等.桑叶提取物对小鼠感染甲型流感病毒FM1的预防与治疗作用研究［J］.中药材,2013,36(11):1837-1842.
［49］王春亮,齐鹏,陈爱荣.桑叶多糖治疗糖尿病机制的研究进展［J］.中国临床药理学杂志,2019,35(1):91-95.
［50］王笃军,康立欣,赵力,等.桑叶经霜对其传统功效清肺润燥作用的影响［J］.天然产物研究与开发,2017,29(9):1546-1550,1601.
Memo
基金项目：国家自然科学基金项目(82104391)；山东省重点研发计划项目（2019GSF108001，2021RZA07034）；山东省自然科学基金青年基金（ZR2016HQ49）；山东省中医药科技发展计划项目（2015-164）