[1] SUN Yansup> FAN Jiaxinsup>LIU Shisup>TANG Mengjuansup> LI Dasup>,.Exploration of Macrophage Polarization Role in PulmonaryFibrosis Based on the Yingwei Theory [J]. Modern Traditional Chinese Medicine, 2024, (05): 1-5. [doi: 10.13424/j.cnki.mtcm.2024.05.001]
Exploration of Macrophage Polarization Role in PulmonaryFibrosis Based on the Yingwei Theory
- Article number:
- 1672-0571(2024)04-0001-06
- Keywords:
- Key words:Yingwei theory; Macrophages; Macrophage polarization; Traditional Chinese Medicine; Pulmonary fibrosis
- ZTFLH:
- R2-03
- Code:
- A
- Abstract:
- Abstract：In recent years，the incidence rate of pulmonary fibrosis (PF) has gradually increased due to environmental pollution and the limitation of treatment methods.With the spread of COVID-19，the pulmonary fibrosis of PF patients has progressed rapidly，and the disease has increasingly attracted the attention of scholars.Previous studies have suggested that the occurrence of PF is closely related to immune cells.Macrophages，as an important component of immune cells，play a crucial role in maintaining the stability of the lung microenvironment and repairing damaged tissues.Macrophages can polarize into two different phenotypes under different microenvironment stimuli：classical activation pathway macrophages (M1) and alternative activation pathway macrophages (M2).The two have different roles in different stages of PF and are highly similar to the traditional Chinese medicine theory of health in terms of composition，function，pathological characteristics，and distribution.Therefore，the article explores the role of macrophage polarization in pulmonary fibrosis through the theory of Yingwei，aiming to expand the application scope of Yingwei theory and provide ideas and theoretical support for the integrated treatment of pulmonary fibrosis with traditional Chinese and Western medicine.
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Memo
基金项目：湖南省自然科学基金青年基金项目（2023JJ40501）；湖南省卫健委重点项目（202203023299）；长沙市自然科学基金项目（kq2202455）