[1] XIANG Lizhu LUO Shushan LI YunboHUANG HaitaoHUANG Wenling BU Xiaoling GENG Weihua,.Analysis of Medication Patterns for Traditional ChineseMedicine Treatment of Adenomyosis Based onHospital Data and Network Pharmacology [J]. Modern Traditional Chinese Medicine, 2024, (05): 104-115. [doi: 10.13424/j.cnki.mtcm.2024.05.019]
Analysis of Medication Patterns for Traditional ChineseMedicine Treatment of Adenomyosis Based onHospital Data and Network Pharmacology
- Article number:
- 1672-0571(2024)04-0100-09
- Keywords:
- Key words:Adenomyosis; Dysmenorrhea; Data mining; Differentiation and treatment rules; Network pharmacology; Mechanism of action; Yanhusuo; Chishao
- ZTFLH:
- R271.9
- Code:
- A
- Abstract:
- Abstract：Objective To analyze the medication pattern and mechanism of action of adenomyosis (AM) through data mining and network pharmacology.Methods Collect traditional Chinese medicine information of patients diagnosed with AM at Dongfang Hospital Affiliated to Beijing University of Traditional Chinese Medicine from January 2017 to December 2020，construct a database for the treatment of AM with traditional Chinese medicine，use the Traditional Chinese Medicine Inheritance Assistance Platform software (V2.5) to analyze medication patterns，use TCMSP to search for high-frequency drug pairs and treatment targets，and map them to Genecards，DisGeNET，DrugBank，and OMIM databases to screen AM targets and take intersections.The STRING data platform constructs a visual protein-protein interactions (PPI) network model，and uses Metascape to perform GO and KEGG enrichment analysis on key targets.Results A total of 1293 prescriptions were collected，including 293 traditional Chinese medicines used，with a total frequency of 21136 times.The nature and taste is mainly characterized by coldness，warmth，bitterness，sweetness，and spiciness in the meridians，with “liver” and “spleen” as the main components.There are 54 association rules and 7 new analysis rules.There are 59 key targets and 157 KEGG pathways for high-frequency drugs to alleviate AM dysmenorrhea with Corydalis yanhusuo and Paeonia lactiflora.The key targets are TNF，AKT1，TP53，VEGFA，IL-6，HIF-1A，MMP9，MMP2，IL-1β，etc.The main pathways are the cancer signaling pathway，PI3K Akt，HIF-1，IL-17 signaling pathway.Conclusion The main drugs for treating AM are those that promote blood circulation，remove blood stasis，relieve pain，and soften hardness，disperse nodules，and eliminate symptoms.The potential signaling pathway of the core drug Yanhusuo Chishao in treating AM dysmenorrhea symptoms can provide ideas for the study of the therapeutic mechanism of traditional Chinese medicine.
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Memo
基金项目：国家青年自然科学基金项目（81704112）