[1] Zhang Miya Ren Yan He Wei Yang Ning,.Research on the Medication Rule of Chief Physician Wang Xisheng in the Treatment of Lung Cancer Based on Latent Structural Model [J]. Modern Traditional Chinese Medicine, 2019, (05): 4-9. [doi: 10.13424/j.cnki.mtcm.2019.05.002]
Research on the Medication Rule of Chief Physician Wang Xisheng in the Treatment of Lung Cancer Based on Latent Structural Model
- Article number:
- 1672-0571(2019)05-0004-06
- Keywords:
- lung cancer; rule of medication; latent structural model
- ZTFLH:
- R734.2
- Code:
- A
- Abstract:
- To explore the rule of medication for the treatment of lung cancer with the chief physician of the famous Chinese medicine Doctor Wang Xisheng in Shaanxi Province. Methods: The prescriptions for lung cancer of Wang Xisheng, a famous doctor in Shaanxi Province, were collected systematically, and the latent structural model ( Lantern 3. 4 software) was constructed. LTM - EAST algorithm was used to learn the latent tree model, and the quality of the model was evaluated by Bayesian information standard score. Quantitative indicators such as mutual information, information coverage rate, latent class probability and conditional probability were used to interpret the variables in the model. The cumulative information coverage rate was 95%, which was used as the interception criterion to interpret the characteristics of latent variables. Artificial interpretation method was used to reveal the law of drug compatibility among the various types of lung cancer. Results: There were 304 prescriptions for lung cancer, totaling 137 Chinese medicines, and 40 Chinese medicines were used more than 20 times. The latent structure model showed that the Bayesian information standard score was - 3779. 35, involving 33 explicit variables and 8 implicit variables, such as Y1 - Y8. Lung cancer patientsmainly suffer from deficiency of both spleen and kidney and stagnation of deficiency and blood stasis. They also suffer from deficiency of kidney, lumbago, phlegm and yin obstructing lung, dampness obstructing middle jiao, deficiency of spleen and kidney, deficiency of essence and blood. Conclusion: Latent structure model combined with artificial interpretation, that is, quantitative and qualitative research methods, can objectively reveal the hidden characteristics of TCM data, and is suitable for the study of the treatment laws of famous and veteran TCM.
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Memo
基金项目：陕西省中医药管理局课题（１５－ＳＣＪＨ００１）