[1] Yu Jingni, L Zeyi, He Junqiang, et al. An Observation on the Effect of Huoxue Huayu Formula on Optic Disc Blood Flow in Glaucoma [J]. Modern Traditional Chinese Medicine, 2020, (06): 66-69,76. [doi: 10.13424/j.cnki.mtcm.2020.06.016]
An Observation on the Effect of Huoxue Huayu Formula on Optic Disc Blood Flow in Glaucoma
- Article number:
- 1672-0571(2020)06-0066-05
- Keywords:
- Huoxue Huayu Formula; blood flow OCT; glaucoma; optic disc
- ZTFLH:
- R775
- Code:
- A
- Abstract:
- Objective To observe the effect of Huoxue Huayu ( activating blood and dispersing stasis) Formula on optic disc blood flow in advanced glaucoma ( glaucoma, glaucoma blindness) through blood flow OCT ( OCTA) . Methods 79 advanced glaucoma patients who were clinically diagnosed as blood stasis and liver associated with kidney deficiency were randomly divided into treatment group and control group among which 48 cases in former with 84 eyes and 31 cases in the latter with 54 eyes. The control group was treated by lowering intraocular pressure while the treatment group was treated by lowering intraocular pressure plus Huoxue Huayu Decoction. 3 months before and after treatment, the best corrected visual acuity ( BCVA) and OCT of each layer of optic disc were tested and observe BCVA as well as optic disc blood flow.Results The BCVA in the treatment group increased in 66 eyes with a total effective rate of 84. 4%, and the visual acuity of the control group increased in 18 eyes with a total effective rate of 33. 3%. There was a significant difference in efficacy between the two groups ( P <0. 05) ; All have significant changes, the total effective rate was greater than 84. 5% while the optic disc blood flow in the control group had only partial changes in the 4 layers of blood vessels, the total effective rate was 24. 1% -31. 5%, so the difference between the two groups was significant ( P < 0. 05) . Conclusion Huoxue Huayu Decoction can significantly increase the blood flow microcirculation of the optic disc, improve the microenvironment of retinal ganglion cells, and ultimately save the impaired visual function by strengthening the body and removing blood stasis, which will become an important treatment to lower intraocular pressure for traditional glaucoma.
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Memo
基金项目:国家自然科学基金面上项目(81273902);西安市卫生局项目(J201601013)
通讯作者:邵娟,副主任医师?E-mail:shaojuan_fly@126.com