[1] LI Mohang SHAO Mingyi ZHENG Guang ZENG Zhenjun GUO Hongtao,.Professor GUO Shuyun's Prescription Rule in The Treatmentof Mild to Moderate Ulcerative Colitis Based on The Network Discrete Derivative Method [J]. Modern Traditional Chinese Medicine, 2021, (04): 47-52. [doi: 10.13424/j.cnki.mtcm.2021.04.011]
Professor GUO Shuyun's Prescription Rule in The Treatmentof Mild to Moderate Ulcerative Colitis Based on The Network Discrete Derivative Method
- Article number:
- 1672-0571(2021)04-0047-06
- Keywords:
- Famous traditional Chinese medicine Doctor; Data mining; Network discrete derivative method; Ulcerative colitis; Medication rule
- ZTFLH:
- R256.34
- Code:
- A
- Abstract:
- Objective To summarize and analyze the medication regularity of Professor GUO Shuyun in treating mild to moderate ulcerative colitis (UC) in the past four years.Methods UC data were extracted from HIS system of the First Affiliated Hospital of Henan University of traditional Chinese medicine. During this period，381 prescriptions of Professor GUO Shuyun for UC patients were collected. The network discrete derivative algorithm based on frequency statistics of sensitive keywords is used to calculate and analyze the prescription of traditional Chinese medicine.Results In the frequency statistics of traditional Chinese medicine prescription，Poria cocos，Purslane，Astragalus，Agrimonia pilosula，Artichoke，Rhizoma Nelumbinis，Fried yam and so on ranked first; In terms of core TCM network，Purslane-Poria cocos-Astragalus-Agrimoniae-Artichoke is the most important TCM network for UC; According to the core drug network，purslane 31g，Poria cocos 19g，Astragalus 14g，Agrimonia pilosa 29g，Artichoke 20g，Lotus root 20g，Aucklandia 12g.Conclusion In the treatment of mild to moderate UC，Professor GUO Shuyun often takes the principle of invigorating the spleen and replenishing Qi，clearing away dampness and heat，regulating Qi and promoting blood circulation，supplemented by special prescriptions and drugs. This study provides a reference for the experience summary of famous TCM doctors.Objective To summarize and analyze the medication regularity of Professor GUO Shuyun in treating mild to moderate ulcerative colitis (UC) in the past four years.Methods UC data were extracted from HIS system of the First Affiliated Hospital of Henan University of traditional Chinese medicine. During this period，381 prescriptions of Professor GUO Shuyun for UC patients were collected. The network discrete derivative algorithm based on frequency statistics of sensitive keywords is used to calculate and analyze the prescription of traditional Chinese medicine.Results In the frequency statistics of traditional Chinese medicine prescription，Poria cocos，Purslane，Astragalus，Agrimonia pilosula，Artichoke，Rhizoma Nelumbinis，Fried yam and so on ranked first; In terms of core TCM network，Purslane-Poria cocos-Astragalus-Agrimoniae-Artichoke is the most important TCM network for UC; According to the core drug network，purslane 31g，Poria cocos 19g，Astragalus 14g，Agrimonia pilosa 29g，Artichoke 20g，Lotus root 20g，Aucklandia 12g.Conclusion In the treatment of mild to moderate UC，Professor GUO Shuyun often takes the principle of invigorating the spleen and replenishing Qi，clearing away dampness and heat，regulating Qi and promoting blood circulation，supplemented by special prescriptions and drugs. This study provides a reference for the experience summary of famous TCM doctors.Objective To summarize and analyze the medication regularity of Professor GUO Shuyun in treating mild to moderate ulcerative colitis (UC) in the past four years.Methods UC data were extracted from HIS system of the First Affiliated Hospital of Henan University of traditional Chinese medicine. During this period，381 prescriptions of Professor GUO Shuyun for UC patients were collected. The network discrete derivative algorithm based on frequency statistics of sensitive keywords is used to calculate and analyze the prescription of traditional Chinese medicine.Results In the frequency statistics of traditional Chinese medicine prescription，Poria cocos，Purslane，Astragalus，Agrimonia pilosula，Artichoke，Rhizoma Nelumbinis，Fried yam and so on ranked first; In terms of core TCM network，Purslane-Poria cocos-Astragalus-Agrimoniae-Artichoke is the most important TCM network for UC; According to the core drug network，purslane 31g，Poria cocos 19g，Astragalus 14g，Agrimonia pilosa 29g，Artichoke 20g，Lotus root 20g，Aucklandia 12g.Conclusion In the treatment of mild to moderate UC，Professor GUO Shuyun often takes the principle of invigorating the spleen and replenishing Qi，clearing away dampness and heat，regulating Qi and promoting blood circulation，supplemented by special prescriptions and drugs. This study provides a reference for the experience summary of famous TCM doctors.
References:
［1］张声生，沈洪，郑凯.溃疡性结肠炎中医诊疗专家共识意见（2017）［J］.中华中医药杂志，2017，32（8）：3585-3589. ［2］Zheng G，Jiang M，He X，et al.Discrete derivative:a data slicing algorithm for exploration of sharing biological networks between rheumatoid arthritis and coronary heart disease［C］.BioData Min，2011 Jun 23;4:18.doi:10.1186/1756-0381-4-18. ［3］夏秋芳，侯乐，张守康，等.基于临床医案的国医大师唐由之用药规律分析［J］.中国中医眼科杂志，2021，31(1):11-16. ［4］许琳，王凤云，李娟娟，等.基于数据挖掘的国医大师治疗溃疡性结肠炎用药规律研究［J］.中国中医药信息杂志，2021，28(5):1-6. ［5］刘建锋，祁向争，高望，等.基于数据挖掘分析李永成教授治疗功能性便秘的用药规律［J］.中国中西医结合消化杂志，2021，29(3):209-213. ［6］Hunter JD.Matplotlib:A 2D Graphics Environment［C］.Computing in Science & Engineering，vol.9，no.3，pp.90-95，2007. ［7］Zheng G，Shi Y，Chen J，et al.Immunoregulation Delivered by the Bioactive Compounds of Dioscoreae Rhizoma［C］.2020 IEEE International Conference on Bioinformatics and Biomedicine（BIBM)，Seoul，Korea(South)，2020，pp.1877-1881，doi:10.1109/BIBM49941.2020.9313271. ［8］Zheng G，Gao Y，Chen J,et al.Immunoenhancement Powered by Astragali Radix with the Tonifying Qi Effect Identified in Chinese Medicine［C］.2020 IEEE International Conference on Bioinformatics and Biomedicine（BIBM)，Seoul，Korea(South)，2020，pp.1340-1345，doi:10.1109/BIBM49941.2020.9313096. ［9］Zheng G，Chen J，Gao Y,et al.Biological Processes underlying the Reinforcing Primary Qi Delivered by Ginseng［C］.2020 IEEE International Conference on Bioinformatics and Biomedicine（BIBM)，Seoul，Korea(South)，2020，pp.1637-1640，doi:10.1109/BIBM49941.2020.9313531. ［10］Guo H，Zheng G，Chen J,et al.Menstrual Regulation Delivered by Angelicae Sinensis Radix［C］.2020 IEEE International Conference on Bioinformatics and Biomedicine（BIBM)，Seoul，Korea（South)，2020，pp.1510-1515，doi:10.1109/BIBM49941.2020.9313147. ［11］Shannon P，Markiel A，Ozier，et al.Cytoscape:a software environment for integrated models of biomolecular interaction networks［J］.Genome Res，2003，Vol.13，pp.2498-2504. ［12］孙林波，郭淑云.郭淑云教授治疗脾胃病经验［J］.现代中医药，2020，40(6):25-28. ［13］李墨航，郭淑云.郭淑云教授辨证论治与专方专药学术思想及验案举隅［J］.中医研究，2020，33(5):41-43. ［14］胡鹏飞，郭淑云.郭淑云从脾虚血瘀论治慢性萎缩性胃炎经验［J］.国医论坛，2019，34(1):57-59. ［15］申丽莎，郭淑云.郭淑云治疗胃食管反流病临床经验［J］.中国民间疗法，2017，25(9):5-6. ［16］王天宁，刘玉婷，肖凤琴，等.马齿苋化学成分及药理活性的现代研究整理［J］.中国实验方剂学杂志，2018，24(6):224-234. ［17］黄兴，王哲，王保和.仙鹤草药理作用及临床应用研究进展［J］.山东中医杂志，2017，36(2):172-176. ［18］杨炳友，杨春丽，刘艳，等.小蓟的研究进展［J］.中草药，2017，48(23):5039-5048. ［19］孙爱静，庞素秋，王国权.中药白及化学成分与药理活性研究进展［J］.环球中医药，2016，9(4):507-511. ［20］黎笑兰，张新广，尹少萍.白芨多糖抑制溃疡性结肠炎大鼠炎性反应与氧化应激［J］.基础医学与临床，2020，40(2):224-228. ［21］卢敏，熊山，牟艳玲.香连丸的化学成分和药理作用研究进展［J］.化学工程师，2018，32(12):68-71.
Memo
基金项目：国家中医药管理局全国名老中医药专家传承工作室建设项目（国中医药人教函［2018］134号）；河南省中医药科学研究专项课题（2018JDZX088）