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[1] ZHAO Meifeng WU Lin SONG Xiaomei TONG Min YUE Ming,.Optimization of Extraction Process of Gantaishu Granules by Box-Behnken Response Surface Method [J]. Modern Traditional Chinese Medicine, 2022, 1(06): 56-61. [doi: 10.13424/j.cnki.mtcm.2022.06.012]

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Optimization of Extraction Process of Gantaishu Granules by Box-Behnken Response Surface Method

Modern Traditional Chinese Medicine[ISSN: 1006-6977/ CN: 61-1281/TN] Volumes & Issues: 1 2022 06 pagination: 56-61 Column: Publication date: 2022-12-10

Article number:: 1672-0571(2022)06-0056-06

Author(s):: ZHAO Meifeng¹ WU Lin¹ SONG Xiaomei² TONG Min¹ YUE Ming¹; 1.Xianyang Central Hospital,Shaanxi Xianyang 712000,China;
2. Shaanxi University of Chinese Medicine, Shaanxi Xianyang 712046,China

Keywords:: Key words:Gantaishu granules; Paeoniflorin; Dry extract; Box-Behnken response surface method; Water extraction process

ZTFLH:: R283.6

DOI:: 10.13424/j.cnki.mtcm.2022.06.012

Code:: A

Abstract:: Abstract：Objective To optimize the extraction process of Gantaishu granules by Box-Behnken response surface method.Methods The effects of water content, decocting time and decocting times on the content of paeoniflorin and the yield of dry extract in Gantaishu granules were investigated by single factor test. Based on the investigation results of single factor test, Box-Behnken response surface method was used to investigate the effects of water addition, decocting time and decocting times on paeoniflorin content and dry extract yield in Gantaishu granules, and binomial equation fitting was conducted to optimize the best water extraction process.Results The binomial fitting equation had good predictability. The best water extraction process was to add 14 times water to the prescription, decoction for 90 min, and decoction for 3 times. Conclusion The process is stable and feasible, which can provide a basis for further research.

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Memo

基金项目：咸阳市二○一九年重点研发计划（2019K02-86）；咸阳市中心医院二○一九年青年创新项目（2019Q02）

Last Update: 2022-11-28