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[1] KONG JingZHOU Bingtuo TANG Jin HE Cong TANG Yishuang WANG Xiaosu PAN Xudi LIU Xia JI Jing,.Effect of Qingxia Huayu Formula Combined with Conventional Western Medicine Therapy on Endotoxins， PCT，IL-6，and IL-10 in Patients with Moderateto Severe Acute Pancreatitis [J]. Modern Traditional Chinese Medicine, 2023, (05): 63-68. [doi: 10.13424/j.cnki.mtcm.2023.05.013]

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Effect of Qingxia Huayu Formula Combined with Conventional Western Medicine Therapy on Endotoxins， PCT，IL-6，and IL-10 in Patients with Moderateto Severe Acute Pancreatitis

Modern Traditional Chinese Medicine[ISSN: 1006-6977/ CN: 61-1281/TN] Volumes & Issues: 2023 05 pagination: 63-68 Column: Publication date: 2023-09-20

Article number:: 1672-0571(2023)05-0063-06

Author(s):: KONG Jing¹; 2ZHOU Bingtuo¹; 2 TANG Jin¹; 2 HE Cong¹; 2 TANG Yishuang1 WANG Xiaosu¹; 2 PAN Xudi¹ LIU Xia1 JI Jing¹; 1.Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200437,China；
2.Digestive Disease Research Laboratory of Integrated Traditional Chinese and Western Medicine，Shanghai 200437,China

Keywords:: Key words:Acute pancreatitis; Qingxia Huayu formula; Endotoxins; Procalcitonin; Inflammatory mediators

ZTFLH:: R256.39

DOI:: 10.13424/j.cnki.mtcm.2023.05.013

Code:: A

Abstract:: Abstract：Objective To evaluate the effect of Qingxia Huayu formula on endotoxin，PCT，IL-6，and IL-10 in patients with acute pancreatitis，and to clarify its antiinflammatory effect.Methods Sixty MSAP or SAP patients were divided into a treatment group of 30 cases and a control group of 30 cases.The control group was treated with conventional Western medicine，while the treatment group was supplemented with Qingxia Huayu formula.After 7 days of treatment，both groups were tested for endotoxin，PCT，cytokines (such as IL-6 and IL-10) to observe clinical efficacy.Results Compared with the control group，the treatment group significantly reduced the levels of gut derived endotoxins，procalcitonin，and IL-6 in AP patients (P<0.01)，while the two groups had no statistically significant impact on IL-10 levels (P>0.05).Conclusion Early combination of Qingxia Huayu formula nasal feeding can reduce intestinal endotoxin translocation，reduce the release of inflammatory mediators，alleviate SIRS，and reduce the incidence of MODS.

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Memo

基金项目：国家自然科学基金委员会青年项目（82004264）；上海市申康医院发展中心中西医临床协作试点建设项目（ZY2018-2020-FWTX-1004）

Last Update: 2023-09-22