[1] SHI Ying ZHANG Ying Wu Ting GUO Yao LIU Xuan LEI Yan ZHANG Wenjing,.Clinical Study on the Treatment of Functional Constipation with Wenyang Tongfu Decoction [J]. Modern Traditional Chinese Medicine, 2023, (06): 74-77. [doi: 10.13424/j.cnki.mtcm.2023.06.016]
Clinical Study on the Treatment of Functional Constipation with Wenyang Tongfu Decoction
- Article number:
- 1672-0571(2023)06-0074-04
- Keywords:
- Key words:Functional constipation; Wenyang Tongfu decoction; Syndrome of Yang deficiency and Yin blood deficiency
- ZTFLH:
- R244.1
- Code:
- A
- Abstract:
- Abstract：Objective To explore the clinical efficacy and safety of Wenyang Tongfu decoction in treating functional constipation with Yang deficiency and Yin blood deficiency syndrome. Methods 143 patients were randomly divided into a treatment group of 72 cases and a control group of 71 cases using a random number table method. Oral administration of Wenyang Tongfu decoction, Mosapride Citrate Dispersible Tablets, and symptomatic supportive treatment were administered separately. Observe the comprehensive clinical efficacy, traditional Chinese medicine syndrome score, colon transit test score, and total clinical symptom score of two groups. Results The total effective rate of the treatment group was 90%, while that of the control group was 77.1%; The difference in TCM symptom score, intestinal transit test score, symptom score, and recurrence rate between the two groups of patients after treatment was statistically significant (P<0.05). Conclusion Wenyang Tongfu decoction can significantly improve the clinical symptoms of functional constipation patients with both Yang deficiency and Yin blood deficiency. It has no toxic side effects or adverse reactions, has a significant therapeutic effect, and a low recurrence rate. It is an effective drug for treating functional constipation.
References:
［1］罗文舟.功能性便秘患者中医体质类型分布的初步研究［D］.南京:南京中医药大学,2017:5-22.
［2］资昌艳,陈诚,丁吉林,等.功能性便秘中医研究进展［J］.实用中医药杂志,2018,34(10):1277-1278.
［3］王燚霈,朱莹,罗敷.功能性便秘穴位敷贴治疗的研究进展［J］.湖南中医杂志,2018,34(9):211-214.
［4］王瑛瑛,路广晁.路广晁治疗功能性便秘经验［J］.光明中医,2010,25(1):12-13.
［5］葛忭巧.自拟益气养血润肠汤治疗习惯性便秘100例［J］.实用中医内科杂志,2011,25(9):52-53.
［6］张丹,夏志伟.功能性便秘的罗马Ⅲ标准［J］.中国医刊,2008,43(12):63-64.
［7］中华医学会外科学分会结直肠肛门外科学组,中华医学会消化病学分会胃肠动力学组.中国慢性便秘诊治指南(2013,武汉)［J］.胃肠病学,2013,18(10):605-612.
［8］中国中西医结合学会消化系统疾病专业委员会.急性胰腺炎中西医结合诊治方案［J］.中国中西医结合消化杂志,2011,19(3):207-209.
［9］周仲瑛.中医内科学［M］.北京:中国中医药出版社,2007.
［10］郑筱萸.中药新药临床研究指导原则［S］.北京:中国医药科技出版社,1997.67.
［11］马相斌.益气活血法治疗功能性便秘［J］.光明中医,2009,24(9):1701.
［12］Papatheodoridis GV,Vlachogiannakos J,Karaitianos I,et al.A Greek survey of community prevalence and characteristics of constipation［J］.European Journal of Gastroenterology & Hepatology,2010,22(3):354-360.
［13］张威.72例中老年功能性便秘患者肛门直肠动力学特点分析［J］.浙江医学,2017,39(1):52-53.
［14］谭艳,李开秀.插管注入开塞露缓解老年患者便秘的效果观察［J］.实用医院临床杂志,2010,7(1):85-86.
［15］李杲.兰室秘藏［M］.北京:人民卫生出版社,1957.
［16］把朝伟.老年功能性便秘的中医辩证治疗［J］.医学信息(上旬刊),2011,24(3):1290-1291.
［17］王利然.加味增液汤直肠滴入治疗小儿功能性便秘42例疗效观察［J］.中国中医药科技,2013,20(1):74.
［18］毛前程,王嘉昀,房天赫等.LC-MS法研究百合地黄汤单煎及共煎液中化学成分变化［J/OL］.辽宁中医药大学学报:1-16
［19］赵婧含,李雪,吴文轩等.熟地黄的化学成分及药理作用研究进展［J］.中医药学报,2023,51(6):110-114.
［20］贺玉琢.熟地黄50%乙醇提取物对血流动态的影响［J］.国外医学(中医中药分册),2005(1):40.
［21］赵素容,卢兖伟,陈金龙等.地黄梓醇降糖作用的实验研究［J］.时珍国医国药,2009,20(1):171-172.
［22］张月月,王君明,巫晓慧.基于以梓醇为主要成分的地黄环烯醚萜苷生物活性研究［J］.中华中医药学刊,2022,40(12):75-77.
［23］胡熙明,张文康,朱庆先,等.中华本草(3)［M］.上海:上海科技出版社,1999:101-114.
［24］陈靖.附子的化学成分研究（Ⅱ）［J］.现代中药研究与实践,2023,37(4):41-44.
［25］崔国宁,周静.附子的临床与基础研究述评［J］.中国中医基础医学杂志,2023,29(9):1576-1581.
［26］赵罗娜,杨元凤,黎豫川等.附子-肉桂配伍调控结肠VIP/cAMP/PKA/AQP通路改善大鼠阳虚型慢传输型便秘［J/OL］.中国实验方剂学杂志:1-13［2023-10-11］.https://doi.org/10.13422z/j.cnki.syfjx,20231212.
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基金项目：陕西省科技厅课题（2022JM-506）