References:

［1］Papi A,Brightling C,Pedersen SE,et al.Asthma［J］.The Lancet,2018,391(10122):783-800.
［2］Zou XL,Chen ZG,Zhang TT,et al.Th17/Treg homeostasis,but not Th1/Th2 homeostasis,is implicated in exacerbation of human bronchial asthma［J］.Therapeutics and Clinical Risk Management,2018,14:1627-1636.
［3］Zhou YM,Zhao HH,Wang TS,et al.Anti-inflammatory and anti-asthmatic effects of TMDCT decoction in eosinophilic asthma through treg/Th17 balance［J］.Frontiers in Pharmacology,2022,13:819728.
［4］Li CC,Sheng AQ,Jia XX,et al.Th17/Treg dysregulation in allergic asthmatic children is associated with elevated Notch expression［J］.The Journal of Asthma:Official Journal of the Association for the Care of Asthma,2018,55(1):1-7.
［5］Lamb D,De Sousa D,Quast K,et al.RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
［J］.Respiratory Research,2021,22(1):158.
［6］Chen TT,Hou XX,Ni YM,et al.The imbalance of FOXP3/GATA3 in regulatory T cells from the peripheral blood of asthmatic patients［J］.Journal of Immunology Research,2018,2018:3096183.
［7］张晶,陈志斌,王春娥,等.基于气道炎症调控的全真一气汤干预肾气虚型哮喘大鼠的机制研究［J］.中国中医急症,2019,28(8):1354-1357.
［8］张晶,严桂珍.全真一气汤治疗肾气虚型支气管哮喘缓解期32例疗效观察［J］.福建中医药,2016,47(3):40-42.
［9］孟鹏飞,吕岳.简述用卵蛋白制作大鼠哮喘模型的要点［J］.甘肃中医学院学报,2011,28(2):27-29.
［10］郑小伟,宋红,王颖,等.肾气虚哮喘模型及中西药联合干预的实验研究［J］.浙江中医杂志,2012,47(2):129-131.
［11］胡健,张至强,曾时杰,等.三拗汤治疗支气管哮喘的研究进展［J］.陕西中医药大学学报,2017,40(6):130-133.
［12］周进进,王娟,李晓娜.哮喘儿童IL-17A rs2275913基因多态性的临床意义［J］.中国妇幼健康研究,2021,32(10):1436-1440.
［13］Wang LL,Wan HY,Tang W,et al.Critical roles of adenosine A2A receptor in regulating the balance of Treg/Th17 cells in allergic asthma［J］.The Clinical Respiratory Journal,2018,12(1):149-157.
［14］Ding FX,Fu Z,Liu B.Lipopolysaccharide exposure alleviates asthma in mice by regulating Th1/Th2 and treg/Th17 balance［J］.Medical Science Monitor:International Medical Journal of Experimental and Clinical Research,2018,24:3220-3229.
［15］雷艳青,陈波.六味地黄丸联合西药对支气管哮喘患者免疫功能的影响［J］.陕西中医,2017,38(4):461-462.
［16］Kudo M,Melton AC,Chen C,et al.IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction［J］.Nature Medicine,2012,18(4):547-554.
［17］Annunziato F,Cosmi L,Liotta F,et al.Defining the human T helper 17 cell phenotype［J］.Trends in Immunology,2012,33(10):505-512.
［18］Bonser LR,Erle DJ.Airway mucus and asthma:the role of MUC5AC and MUC5B［J］.Journal of Clinical Medicine,2017,6(12):112.
［19］Suzuki Y,Maazi H,Sankaranarayanan I,et al.Lack of autophagy induces steroid-resistant airway inflammation［J］.Journal of Allergy and Clinical Immunology,2016,137(5):1382-1389.e9.
［20］Al Heialy S,Gaudet M,Ramakrishnan RK,et al.Contribution of IL-17 in steroid hyporesponsiveness in obese asthmatics through dysregulation of glucocorticoid receptors α and Β［J］.Frontiers in Immunology,2020,11:1724.
［21］Yu Q,Shi YJ,Shu C,et al.Andrographolide inhibition of Th17-regulated cytokines and JAK1/STAT3 signaling in OVA-stimulated asthma in mice［J］.Evidence-Based Complementary and Alternative Medicine:ECAM,2021,2021:6862073.
［22］Fasching P,Stradner M,Graninger W,et al.Therapeutic potential of targeting the Th17/treg axis in autoimmune disorders［J］.Molecules,2017,22(1):134.
［23］Xin L,Gao JJ,Ge XH,et al.Increased pro-inflammatory cytokine-secreting regulatory T cells are correlated with the plasticity of T helper cell differentiation and reflect disease status in asthma［J］.Respiratory Medicine,2018,143:129-138.
［24］Shaaban R,Zureik M,Soussan D,et al.Rhinitis and onset of asthma:a longitudinal population-based study［J］.The Lancet,2008,372(9643):1049-1057.
［25］Ming MY,Luo ZX,Lv SQ,et al.Inactivated Mycobacterium phlei inhalation ameliorates allergic asthma through modulating the balance of CD4+CD25+ regulatory T and Th17 cells in mice［J］.Iranian Journal of Basic Medical Sciences,2016,19(9):953-959.
［26］叶峥嵘,孟淑华.对中医药免疫研究的思考［J］.陕西中医药大学学报,2017,40(5):10-12,18.
［27］吴芳,张宏方.中医平衡系统与西医免疫—监视—抑瘤平衡理论的探讨［J］.现代中医药,2014,34(6):62-64.［知网］
［28］冯兆张.冯氏锦囊秘录［M］.田思胜,校注.北京:中国中医药出版社,1996:526.
［29］李信翰,张建伟.中国古代医易学说探究［J］.现代中医药,2018,38(1):58-62,65.