[1] YU Ruxia LIU Wenshuo WANG Qiucheng JIANG Jing,.Analysis of the Medication Rules for Preventing and TreatingSenile Dementia in the Compendium of Materia Medica [J]. Modern Traditional Chinese Medicine, 2024, (06): 30-35. [doi: 10.13424/j.cnki.mtcm.2024.06.006]
Analysis of the Medication Rules for Preventing and TreatingSenile Dementia in the Compendium of Materia Medica
- Article number:
- 1672-0571(2024)04-0031-05
- Keywords:
- Key words:Compendium of Materia Medica; Forgetfulness; Senile dementia; Drug analysis; Medicine and food share the same origin
- ZTFLH:
- R256.23
- Code:
- A
- Abstract:
- Abstract：Objective To analyze the pharmacological characteristics of drugs related to “forgetfulness” in the ancient literature of Compendium of Materia Medica, in order to provide literature basis for the prevention and treatment of senile dementia. Methods Taking LIU Hengru and LIU Shanyong’s proofreading of the Compendium of Materia Medica as the research object, screened drugs related to “forgetfulness”, established a database, and analyzed their pharmacological characteristics. Results A total of 56 drugs that can treat forgetfulness and 7 drugs that can cause forgetfulness were screened in the Compendium of Materia Medica under the categories of “Indications for All Diseases-Forgetfulness” and “Water Department-Human Department”. The natural properties of drugs that can treat forgetfulness are mainly concentrated in the grass (41.07%), followed by the gold and wood parts; The main medicinal properties are mild (38.78%), followed by cold and warm; The main medicinal flavors are spicy, sweet, and bitter (accounting for 38.10%, 30.95%, and 26.19% respectively); The toxicity of drugs is mainly non-toxic drugs (accounting for 83.67%). Medications that can cause forgetfulness are mainly characterized by their moderate, warm, and pungent taste, and often have certain toxicity. Conclusion The study found that the Compendium of Materia Medica records a wealth of drugs for treating Alzheimer’s disease, which can provide certain guidance for the clinical use of drugs and provide literature basis for further exploring the prevention and treatment of Alzheimer’s disease from the perspective of medication and diet regulation.
References:
［1］周思静，罗邦安，曹慧，等.≥65岁居民老年痴呆流行病学特征及其与慢性病共病的相关性研究[J].中国全科医学，2023，26(29)：3616-3621.
[2]WU YT，BEISER AS，BRETELER M MB，et al.The changing prevalence and incidence of dementia over time-current evidence[J].Nat Rev Neurol，2017，13(6)：327-339.
[3]ORGANIZATION WH.（2022）Available online at：https://www.who.int/news-room/fact-sheets/detail/dementia.
[4]SCHELTENS P，DE STROOPER B，KIVIPELTO M，et al.Alzheimer’s disease[J].Lancet，2021，397(10284)：1577-1590.
[5]王朋，梅嵘，杨学青，等.基于“神志病”视角探讨阿尔茨海默病从交通心肾论治[J].中国中医基础医学杂志，2023，29(8)：1384-1386.
[6]谭爱华，宋子瑜，石和元，等.李时珍对健忘的认识及《本草纲目》治疗健忘的药物特点分析[J].时珍国医国药，2020，31(7)：1752-1754.
[7]可夫，谷英敏，马纲.中国食材分类方法浅析[J].中华中医药杂志，2011，26(10)：2217-2220.
[8]万德华.论陶弘景对本草学的贡献[J].中国民族民间医药，2015，24(23)：48-49.
[9]方金苗，杜武勋.中药四气、五味药性物质基础研究[J].辽宁中医药大学学报，2015，17(12)：66-68.
[10]李艺博，张晶新，李腾腾，等.五味理论的现代医学研究[J].中华中医药杂志，2023，38(4)：1417-1420.
[11]王冰.黄帝内经素问[M].北京：人民卫生出版社，2005：22.
[12]王宇阳，马放，占永立.从《伤寒杂病论》中治疗肾病的经方诠释中药四气五味理论[J].中医杂志，2019，60(5)：366-369.
[13]杨泽，汪翔，万锡钢，等.“淡味渗泄为阳”理论探微[J].中华中医药杂志，2022，37(7)：3832-3834.
[14]秦华珍.酸味、涩味药药性、化学成分、药理作用探讨[J].湖南中医学院学报，1998，(3)：65-66.
[15]李泓涛，李胜涛.浅谈药物的“毒性”[J].湖南中医杂志，2016，32(3)：145-146.
[16]张雷，范占芳，张作鹏，等.阿尔兹海默症发病机制及相关治疗药物的研究进展[J].中国药物化学杂志，2021，31(6)：438-446，469.
[17]KHOURY R，RAJAMANICKAM J，GROSSBERG GT.An update on the safety of current therapies for Alzheimer’s disease：focus on rivastigmine[J].Ther Adv Drug Saf，2018，9(3)：171-178.
[18]MARTNEZ-LAPISCINA EH，CLAVERO P，TOLEDO E，et al.Mediterranean diet improves cognition：the PREDIMED-NAVARRA randomised trial[J].J Neurol Neurosurg Psychiatry，2013，84(12)：1318-1325.
[19]VALLS-PEDRET C，SALA-VILA A，SERRA-MIR M，et al.Mediterranean Diet and Age-Related Cognitive Decline：A Randomized Clinical Trial[J].JAMA Intern Med，2015，175(7)：1094-1103.
[20]任娟莉.《千金要方》“药食同源”方药探析[J].陕西中医，2009，30(3)：350-351.
[21]李媛媛，于良晓，裴海生，等.药食同源生物活性物质降脂减重机制研究进展[J].食品安全质量检测学报，2022，13(22)：7407-7414.
[22]徐飞飞，管雅琪，崔恺，等.党参-茯苓-甘草水提物通过激活胆碱能信号通路改善痴呆小鼠的学习记忆功能[J].现代食品科技，2021，37(10)：19-29，290.
[23]刘改枝，朱奕林，许杜娟，等.山药活性成分抗老年痴呆症的网络药理学作用机制探讨[J].中药新药与临床药理，2021，32(3)：374-382.
[24]龙清华，赵宾宾，丁莉，等.酸枣仁汤通过抑制神经炎症和改善神经营养水平促进APP/PS1痴呆小鼠海马神经发生[J].世界科学技术-中医药现代化，2021，23(9)：3014-3022.
[25]LONG QH，WU YG，HE LL，et al.Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice[J].Chin Med，2021，16(1)：14.
[26]LI H，LEI T，ZHANG J，et al.Longan (Dimocarpus longan Lour.) Aril ameliorates cognitive impairment in AD mice induced by combination of D-gal/AlCl(3) and an irregular diet via RAS/MEK/ERK signaling pathway[J].J Ethnopharmacol，2021，267：113612.
[27]冉玉兵，刘磊，张瑞芬，等.龙眼果肉提取物改善SAMP8小鼠学习记忆功能[J].现代食品科技，2017，33(6)：1-8.
Memo
基金项目：国家自然科学基金面上项目（82174515）