Pre Next

[1] HUYAN Xinna ??HU Xinghua ??WANG Xiaolin??LU Fenping??XU Jianqin??GAO Yuan,.Data Mining of Drug Law of Qian Jin Fang in Treating Diabetes [J]. Modern Traditional Chinese Medicine, 2023, (01): 31-35. [doi: 10.13424/j.cnki.mtcm.2023.01.006]

Copy

Data Mining of Drug Law of Qian Jin Fang in Treating Diabetes

Modern Traditional Chinese Medicine[ISSN: 1006-6977/ CN: 61-1281/TN] Volumes & Issues: 2023 01 pagination: 31-35 Column: Publication date: 2023-01-20

Article number:: 1672-0571(2023)01-0031-05

Author(s):: HUYAN Xinna ¹??HU Xinghua ²??WANG Xiaolin²??LU Fenping²??XU Jianqin²??GAO Yuan²?; 1.Ningxia Medical University，Yinchuan 750000，China;
2.Shaanxi Academy of Chinese Medicine，Xian 710003，China

Keywords:: Diabetes; Qian Jin Fang; Cold and warm; Data mining

ZTFLH:: R255.4

DOI:: 10.13424/j.cnki.mtcm.2023.01.006

Code:: A??

Abstract:: Objective To sort out the oral prescriptions for diabetes in two Qian Jin Fang and explore the regularity of their use.Methods With the help of Zhong Hua Yi Dian (V5)，we screened the internal prescriptions for diabetes in Qian Jin Fang，formed text data and entered them into the traditional Chinese medicine inheritance assistance system platform (V3.0) for frequency analysis，association rules and other analysis.Results A total of 80 prescriptions were collected，involving 143 Chinese herbs.The frequently used drugs are Trichosanthin (34 times，42.5%)，Licorice (22 times，27.5%)，Poria cocos (22 times，27.5%)，Ophiopogon japonicus (22 times，27.5%)，Coptis chinensis (17 times，21.3%)，Rehmannia glutinosa (15 times，18.8%)，Cinnamon twig (12 times，15.00%)，etc.The corresponding drug properties are mainly cold (30.5%)，warm (22.2%)，and the drug flavors are mainly sweet (52.8%) and bitter (31.6%)；The first three kinds of drugs with higher efficacy frequency were tonic (24.1%)，heat clearing (17.6%) and moisture permeability (7.6%)；Association rule analysis showed that 13 groups of high-frequency drug pairs with support ≥8，the first three were respectively Trichosanthin → Licorice，Tuckahoe →Ginseng，Tuckahoe →Licorice；There are 8 association rules with confidence ≥ 0.7.The first four related drugs are “Licorice，Ophiopogon japonicus → Tuckahoe”,“Ginger →Licorice，Trichosanthin”,“Ophiopogon japonicus →Tuckahoe，Trichosanthin”,“Licorice →Tuckahoe”.Conclusion Qian Jin Fang is mainly used to nourish Yin，clear heat and strengthen the spleen in treating diabetes，which is worth learning from.

References:

［1］张印生,韩学杰.孙思邈医学全书(唐宋金元名医全书大成)(精)［M］.北京：中国中医药出版社,2012.
［2］昌静楠,张玉,陈玉状.黄元御中气理论治疗消渴病的探析［J］.中医药临床杂志,2021,33(7):1234-1237.
［3］崔小跃,张冰冰.基于中气升降理论从内生火邪论消渴病机［J］.中国中医药现代远程教育,2020,18(17):59-61.
［4］谭艳,左新河,赵勇,等.基于中医传承辅助平台挖掘《外台秘要》消渴病方剂组方规律［J］.光明中医,2021,36(7):1027-1030.
［5］李恩庆,陈孝银.《备急千金要方》中消渴病证治探要［J］.四川中医,2003,21(4):2-3.
［6］陶乐维,陆灏.浅析《备急千金要方》对消渴病论述的继承与创新［J］.中华中医药杂志,2016,31(12):4928-4930.
［7］童晓青.隋唐医家论消渴病述略［J］.中医函授通讯,2000,18(6):17-18.
［8］李璐,路新国.《千金方》治疗消渴特色［J］.河南中医,2010,30(11):1138-1139.
［9］李琼,张鹏,郭晨,等.天花粉凝集素对2型KK-Ay糖尿病小鼠血糖、血脂的调节作用［J］.西南大学学报(自然科学版),2016,38(2):182-188.
［10］王莉,李松林,王涛.降血糖植物多糖和糖甙研究进展［J］.中药材,2000,23(9):575-579.
［11］任玲.甘草苷酶解法制备甘草素工艺优化及其降糖保肝活性研究［D］.长春：吉林农业大学,2016.
［12］王源,王硕,王令仪,等.麦冬多糖MDG-1对糖尿病小鼠模型的降糖作用［J］.上海中医药大学学报,2011,25（4):66-70.
［13］唐姗,何忠梅,任珅,等.不同比例人参皂苷Re与黄连素配伍对2型糖尿病降糖作用的研究［J］.上海中医药杂志,2016,50(8):86-89.
［14］马伯艳,李寒,李云凤,等.黄连及其有效成分降糖作用的研究进展及量效关系［J］.中成药,2019,41(12):2970-2973.
［15］吴玲玲,孙慧.黄连素降糖机制的研究［J］.实用心脑肺血管病杂志,2020,28(S1):262-264.
［16］赵平鸽,刘晓.地黄多糖的提取纯化及其对糖尿病小鼠血糖的影响研究［J］.海峡药学,2010,22(9):29-32.
［17］沈仕伟,仝小林.《千金方》消渴病证治特色及其对后世的影响［J］.上海中医药杂志,2017,51(12):39-41.
［18］吴华英,潘继兴,邓文祥,等.浅析仲景辨治消渴病思想［J］.江西中医药大学学报,2017,29(1):1-2,23.

Memo

基金项目：国家中医药管理局医史文献重点学科建设单位项目［国中医药发（2009）30号］；北京中医药大学孙思邈研究院科研计划项目（SSMYJY2202013）

Last Update: 2023-01-20