[1]陈兴慧 刘 力 唐旭东＊＊ 张聪伟 杜晓泉 马小兵 吕小龙.温阳止泻汤治疗功能性腹泻脾肾阳虚证临床研究[J].现代中医药,2017,(04):021-24.[doi:10.13424/j.cnki.mtcm.2017.04.009]
　Chen Xinghui Liu Li Tang Xudong Zhang Congwei Du Xiaoquan Ma Xiaobing Lv Xiaolong.Clinical Ｒesearch on Treatment of Functional Diarrhea of Yang－deficiency Pattern with Yang－warming and Diarrhea－stopping Decoction[J].Modern Traditional Chinese Medicine,2017,(04):021-24.[doi:10.13424/j.cnki.mtcm.2017.04.009]
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温阳止泻汤治疗功能性腹泻脾肾阳虚证临床研究()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2017年04期
页码:
021-24
栏目:
临床研究
出版日期:
2017-07-05

文章信息/Info

Title:
Clinical Ｒesearch on Treatment of Functional Diarrhea of Yang－deficiency Pattern with Yang－warming and Diarrhea－stopping Decoction
文章编号:
1672－0571(2017)04－0019－04
作者:
陈兴慧1 刘 力2 唐旭东3＊＊ 张聪伟1 杜晓泉1 马小兵2 吕小龙4
1．陕西中医药大学附属医院，陕西 咸阳 712000; 2． 陕西中医药大学，陕西 咸阳 712046; 3．中国中医科学院西苑医院，北京 100091; 4．陕西省中医医院，陕西 西安 710000
Author(s):
Chen Xinghui1 Liu Li2 Tang Xudong3 Zhang Congwei1 Du Xiaoquan1 Ma Xiaobing2 Lv Xiaolong4
1． The Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang 712000，China; 2． Shaanxi University of Chinese Medicine，712046 Xianyang ，China; 3． Xiyue Hospital of Chinese Academy of Medical Sciences，Beijing 100091，China; 4． Shaanxi Provinc
关键词:
功能性腹泻;  脾肾阳虚;  温阳止泻汤;  临床研究
Keywords:
functional diarrhea; yang－deficiency of spleen and kidney; Yang－warming and Diarrhea－stopping De- coction; clinical research
分类号:
Ｒ256.34
DOI:
10.13424/j.cnki.mtcm.2017.04.009
文献标志码:
B
摘要:
目的 观察温阳止泻汤治疗脾肾阳虚型功能性腹泻的临床疗效、安全性，并探讨其机理。方法 将 60 例纳入的患者按就诊顺序随机分为两组，治疗组 30 例服用温阳止泻汤治疗，对照组 30 例给予安慰剂治疗， 两组均服药 28 天。治疗前后进行安全性观察，记录两组前后中医证候和积分变化，并进行比较。结果 治疗组 患者大便性状、畏寒肢冷、腰膝酸软优于对照组( P＜0．05) ; 治疗组排便频次、食欲不振、神疲乏力等与对照组对 比疗效相当( P＞0．05) ; 在中医证候疗效及中医症状总积分方面，温阳止泻汤组明显优于对照组( P＜0．05) ; 两组 患者治疗前后分别检测相关安全性指标，均未发现明显异常，安全可靠。结论 温阳止泻汤可有效治疗脾肾阳虚 型功能性腹泻，无不良反应，值得临床推广应用。
Abstract:
Objective: To observe the clinical effect of the Yang－warming and Diarrhea－stopping Decoction on func- tional diarrhea classified into pattern of yang－deficiency of spleen and kidney and evaluate its safety and further to explore its mechanisms． Method: Totally 60 patients were evenly divided into treatment and control groups according to their hos- pitalized numbers． The control group received placebo while the treatment group accepted the Yang－warming and Diarrhea －stopping Decoction for 28 days． The comparison of drug’s safety and changes of TCM symptoms as well as integral inde- xes was conducted before and after treatment． Ｒesults: The symptoms of stool form，aversion to cold and limbs chilliness， soreness and weakness of waist and knees in the treatment group were all superior to those in the control group ( P＜0．05) ．Defecation frequency，anorexia and lassitude of the two groups were similar ( P＞0．05) ． The total TCM symptoms and inte- gral indexes of the treatment group were obviously superior to those of the control group ( P＜0．05) ． However，there ap- peared no danger indexes in both groups． Conclusion: Yang－warming and Diarrhea－stopping Decoction is effective in treating functional diarrhea belonging to yang－deficiency of spleen and kidney，with no side effect and worthy of populari- zing in clinical application．

参考文献/References:

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[2]郑筱萸．中药新药临床研究指导原则( 试行) ［M]．北京: 中国医药科技出版社，2002: 139－143．
[3]周仲英．中医内科学( 普通高等教育“十一五”规划教 材) ［M]．北京: 中国中医药出版社，2008: 234－239．
[4]余牧．补脾柔肝方治疗腹泻型肠易激综合征 56 例临床 研究［J]．陕西中医药大学学报，2016，39( 5) : 47－48．
[5]潘东梅，王邦才．王邦才教授运用附子经验举隅［J]．陕 西中医学院学报，2015，38( 1) : 20－22．
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备注/Memo

备注/Memo:
收稿日期:2017－05－09编辑:孙理军＊ ＊＊
基金项目:国家“973”重点科技支撑计划项目(2013CB531703)
通讯作者:唐旭东(1963－)，男，教授，主任医师，教授，研究方向:中西医结合防治消化系统疾病的临床和实验研究。E－mail:txdly@163．com
更新日期/Last Update: 2017-07-15