[1]陈晓群　贾 钢.清热益肾汤联合缬沙坦治疗高血压早期肾损害临床研究[J].现代中医药,2019,(04):050-53.[doi:10.13424/j.cnki.mtcm.2019.04.015]
　Chen Xiaoqun Jia Gang.Clinical Study on Qingre Yishen Decoction Combined with Valsartan in Treating Early Renal Damage of Hypertension[J].Modern Traditional Chinese Medicine,2019,(04):050-53.[doi:10.13424/j.cnki.mtcm.2019.04.015]
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清热益肾汤联合缬沙坦治疗高血压早期肾损害临床研究 ()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2019年04期
页码:
050-53
栏目:
临床研究
出版日期:
2019-07-15

文章信息/Info

Title:
Clinical Study on Qingre Yishen Decoction Combined with Valsartan in Treating Early Renal Damage of Hypertension
文章编号:
1672 -0571( 2019) 04 -0050 -04
作者:
陈晓群　贾 钢
西安市长安区医院，陕西西安 ７１０１００
Author(s):
Chen Xiaoqun Jia Gang
Chang’ an District Hospital of Xi’ an, Xi’ an China, 710100
关键词:
高血压早期肾损害; 清热益肾汤; 缬沙坦; 肾动脉; 肾功能
Keywords:
early renal damage of hypertension;  Qingre Yinshen Decoction;  valsartan;  renal artery;  renal function
分类号:
R544.1
DOI:
10.13424/j.cnki.mtcm.2019.04.015
文献标志码:
B
摘要:
目的分析探讨清热益肾汤联合缬沙坦对高血压早期肾损害患者肾动脉血流动力学和肾功能的影响?方法选取我院于2017年12月~2018年12月期间收治的220例高血压早期肾损害患者,按照随机数字表法将所有患者简单随机分为对照组和治疗组,所有患者均给予缬沙坦胶囊进行治疗,而治疗组患者则在此基础上联合使用清热益肾汤进行治疗,两组患者均连续治疗12周?观察两组患者治疗前后的肾功能指标变化情况和肾动脉血流动力学变化情况,比较两组患者的不良反应发生率和临床疗效?结果两组患者治疗前的肾动脉血流动力学指标并无明显差异(均P>0.05);经过治疗后两组患者的肾动脉血流动力学指标均显著优于本组治疗前(均P<0.05),治疗组患者经过治疗后的肾动脉血流动力学指标均显著优于同期对照组患者(均P<0.05)?两组患者治疗前的肾功能指标并无明显差异(均P>0.05);经过治疗后两组患者的肾功能指标均显著优于本组治疗前(均P<0.05),治疗组患者经过治疗后的肾功能指标均显著优于同期对照组患者(均P<0.05)?两组患者在治疗期间均未出现关节痛?头晕等不良反应;治疗组患者的总有效率为91.82%,显著高于对照组患者的73.64%(χ2=9.273,P<0.05)?结论对高血压早期肾损害患者采用缬沙坦胶囊联合清热益肾汤进行治疗能够有效促进其肾功能指标的恢复和改善其肾动脉血流状况,安全性高并且效果显著,值得在临床上加以推广运用?
Abstract:
To investigate the effects of Qingre Yishen Decoction combined with valsartan on renal artery hemodynamics and renal function in patients with early renal damage of hypertension. Methods: 220 patients with hypertensive early renal damage admitted to our hospital from December 2017 to December 2018 were randomly divided into control group and treatment group. All patients were treated with valsartan capsule, while patients in treatment group were treated with Qingre Yishen Decoction on this basis. Both groups were treated continuously for 12 weeks. The changes of renal function indexes and renal artery hemodynamics were observed before and after treatment, and the incidence of adverse reactions and clinical efficacy were compared between the two groups. Results: There was no significant difference inrenal artery hemodynamic indexes between the two groups before treatment ( all P > 0. 05) ; after treatment, the renal artery hemodynamic indexes of the two groups were significantly better than those of the group before treatment ( all P < 0.05) ; after treatment, the renal artery hemodynamic indexes of the treatment group were significantly better than those of the control group at the same time. There was no significant difference in renal function indexes between the two groups before treatment ( all P > 0. 05) ; after treatment, the renal function indexes of the two groups were significantly better than those before treatment ( all P < 0. 05) , and the renal function indexes of the treatment group were significantly better than those of the control group after treatment ( all P < 0. 05) . No adverse reactions such as joint pain and dizziness occurred in the two groups during the treatment period. The total effective rate of the treatment group was 91. 82%, which was significantly higher than that of the control group ( 73. 64% ( x 2 = 9. 273, P < 0. 05) . Conclusion: Valsartan capsule combined with Qingre Yishen Decoction can effectively promote the recovery of renal function index and improve the renal artery blood flow in patients with early renal damage of hypertension. It has high safety and remarkable effect? and is worthy of clinical promotion.

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备注/Memo

备注/Memo:
收稿日期：２０１８－１０－１２ 编辑：巩振东
更新日期/Last Update: 2019-07-15