[1]童静 李鹏飞.黄葵胶囊联合 ACEI/ ARB 类药物治疗慢性肾炎疗效及安全性 Meta 分析[J].现代中医药,2020,(05):029-38.[doi:10.13424/j.cnki.mtcm.2020.05.008]
　Tong Jing,Li Pengfei.Meta Analysis of Efficacy and Safety of Huangkui Capsule Combined with ACEI/ ARB Drugs in the Treatment of Chronic Nephritis[J].Modern Traditional Chinese Medicine,2020,(05):029-38.[doi:10.13424/j.cnki.mtcm.2020.05.008]
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黄葵胶囊联合 ACEI/ ARB 类药物治疗慢性肾炎疗效及安全性 Meta 分析()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2020年05期
页码:
029-38
栏目:
出版日期:
2023-11-20

文章信息/Info

Title:
Meta Analysis of Efficacy and Safety of Huangkui Capsule Combined with ACEI/ ARB Drugs in the Treatment of Chronic Nephritis
文章编号:
1672-0571(2020)05-0029-11
作者:
童静1 李鹏飞2
1.西安医学院第一附属医院,陕西西安710077;
2.西安交通大学第一附属医院,陕西西安710061
Author(s):
Tong Jing 1 ;  Li Pengfei 2
1. The First Affiliated Hospital of Xi ＇an Medical University, Xi’ an Shaanxi 710077;
2. The First Affiliated Hospital of Xi ＇an Jiaotong University, Xi’ an Shaanxi 710061
关键词:
黄葵胶囊; 慢性肾炎; ACEI; ARB; Meta分析
Keywords:
Huangkui capsule;  Chronic nephritis;  ACEI. ;  ARB;  Meta analysis
分类号:
R692.3
DOI:
10.13424/j.cnki.mtcm.2020.05.008
文献标志码:
A
摘要:
目的系统评价黄葵胶囊联合ACEI/ARB类药物治疗慢性肾炎(CGN)疗效及安全性,为临床提供循证参考?方法在PubMed? Medline? Cochrane 图书馆?EMBASE?中国生物医学文献数据库?万方数据库?中国知网?维普期刊数据库中进行检索,搜集有关黄葵胶囊联合ACEI/ARB类药物治疗CGN的随机对照试验(RCT)或半随机对照试验(qRCT),采用RevMan5.3统计软件进行Meta分析?结果共纳入35项RCT或qRCT,纳入2505例患者?Meta分析结果显示,与对照组相比,试验组可以降低CGN患者24h尿蛋白定量(24hUTP)[OR=0.38,95%CI(0.30,0.46),P<0.00001]?血肌酐(Scr)[OR=14.58,95%CI(6.57,22.60),P=0.001]及尿氮素(BUN)[OR=0.54,95%CI(0.28,0.79),P<0.0001];升高CGN患者血浆白蛋白(ALB)[OR=4.10,95%CI(2.07,6.13),P<0.0001];提高CGN患者治疗的总有效率[OR=4.61,95%CI(3.59,5.91),P<0.00001];减少患者不良反应的发生[OR=1.88,95%CI(1.09,3.24),P=0.02]?结论黄葵胶囊联合ACEI/ARB类药物与单用ACEI/ARB类药物相比,能提高总有效率,降低24hUTP?Scr及BUN,升高ALB,减少患者不良反应的发生,亚组分析显示试验组治疗CGN优于对照组?
Abstract:
Objective To systematically evaluate the efficacy and safety of Huangkui capsule combined with ACEI/ARB drugs in the treatment of chronic nephritis ( CGN) , providing evidence - based reference for clinical practice. Methods To Search in PubMed, Medline, Cochrane Library, EMBASE, Chinese Biomedical Literature Database, Wanfang Database, CnKI, and Weipu journal database and collect randomized controlled trials ( RCTS) or semi – rcTs ( qRCT) of Huang Kui capsule combined with ACEI/ ARB drugs for CGN. The RevMan 5. 3 statistical software is used for Meta analysis. Results A total of 35 ITEMS of RCT or qRCT and 2505 patients were included. Meta analysis results indicated that the experimental group could reduce the urinary protein quantification ( 24hUTP) of CGN patients for 24h [ OR = 0. 38, 95%CI ( 0. 30, 0. 46) , P < 0. 00001] , serum creatinine ( Scr) [ OR = 14. 58, 95%CI ( 6. 57, 22. 60) , P=0. 001] and urinary nitrogen ( BUN) [ OR = 0. 54, 95%CI ( 0. 28, 0. 79) , P < 0. 0001] compared with the control group, increasing plasma albumin ( ALB) in CGN patients [ OR = 4. 10, 95% CI ( 2. 07, 6. 13) , P < 0. 0001] . The total effective rate of CGN patients was improved [ OR = 4. 61, 95% CI ( 3. 59, 5. 91) , P < 0. 00001] , reducing the incidence of adverse reactions in patients [ OR = 1. 88, 95% CI ( 1. 09, 3. 24) , P = 0. 02] . Conclusion Compared with ACEI/ ARB drugs alone, Huangkui capsule combined with ACEI/ ARB drugs can improve the total effective rate, reducing 24hUTP, Scr and BUN, increasing ALB, and reducing the occurrence of adverse reactions in patients. Subgroup analysis showed that the treatment of CGN in the test group was better than the control group.

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备注/Memo

备注/Memo:
基金项目:西安医学院第一附属医院科研项目(XYFY2015-04) 通讯作者:李鹏飞,中级药师?E-mail:475118038@qq.com
更新日期/Last Update: 2020-09-17