[1]于萧 孔旋 刘俊 李锋.益气活血利水法治疗特发性膜性肾病临床研究[J].现代中医药,2022,1(02):079-83.[doi:10.13424/j.cnki.mtcm.2022.02.014]
　YU Xiao KONG Xuan LIU Jun LI Feng.Clinical Study on Treatment of Idiopathic Membranous Nephropathy by Yiqi Huoxue Lishui Method[J].Modern Traditional Chinese Medicine,2022,1(02):079-83.[doi:10.13424/j.cnki.mtcm.2022.02.014]
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益气活血利水法治疗特发性膜性肾病临床研究
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
1
期数:
2022年02期
页码:
079-83
栏目:
临床精粹
出版日期:
2022-04-16

文章信息/Info

Title:
Clinical Study on Treatment of Idiopathic Membranous Nephropathy by Yiqi Huoxue Lishui Method
文章编号:
1672-0571(2022)02-0079-05
作者:
于萧1 孔旋2 刘俊3 李锋4
1.陕西中医药大学第二附属医院，陕西 咸阳712000；
2.西安航空学院，陕西 西安710000；
3.西安市妇幼保健院，陕西 西安 712000；
4.空军军医大学西京医院，陕西 西安 710032
Author(s):
YU Xiao1 KONG Xuan2 LIU Jun3 LI Feng4
1.The Second Affiliated Hospital of Shaanxi University ofTraditional Chinese Medicine，Shaanxi Xianyang 712000,China；
2.Xi'an Aviation College，Xi'an 710000,China；
3.Xi'an Maternal and Child Health Hospital，Xi'an 712000,China；
4.Xijing Hospital of Air Force Military Medical University，Xi'an 710032,China
关键词:
关键词：膜性肾病; 益气活血利水法; 气虚血瘀型
Keywords:
Key words：Membranous nephropathy; Supplementing qi; activating blood circulation and promoting diuresis; Qi deficiency and blood stasis type
分类号:
R256.51
DOI:
10.13424/j.cnki.mtcm.2022.02.014
文献标志码:
A
摘要:
摘 要：目的 观察益气活血利水法治疗特发性膜性肾病的临床疗效，探索中医治疗特发性膜性肾病的诊疗思路。方法 本研究为回顾性研究，数据来源于2015年3月-2017年6月西京医院中医科、肾内科门诊及住院部膜性肾病患者30例，分为对照组与治疗组，每组各15例，进行西药治疗和中药联合西药治疗，观察24周，分别对24小时尿蛋白定量、血清白蛋白、肌酐等实验室指标进行统计分析，同时观察患者症状改善、中医症候积分变化等，对中医药治疗膜性肾病疗效做出评价。结果 治疗组总有效率73.3%，对照组总有效率46.7%，在降低患者24小时尿蛋白定量、降低血脂、改善患者水肿、乏力、腰膝酸软、肢体麻木等症状效果优于单纯西药组，在升高血浆总蛋白、白蛋白方面效果相当，两组治疗前后均无肝肾功能损害。结论 益气活血利水中药联合西医治疗气虚血瘀型特发性膜性肾病效果优于单纯西药组，临床疗效确切。
Abstract:
Abstract：Objective To observe the clinical efficacy of Yiqi Huoxue Lishui method in the treatment of idiopathic membranous nephropathy and explore the diagnosis and treatment ideas of traditional Chinese medicine in the treatment of idiopathic membranous nephropathy.Methods This study was a retrospective study.The data came from 30 patients with membranous nephropathy in the outpatient and inpatient departments of traditional Chinese medicine and Nephrology of Xijing Hospital from March 2015 to June 2017.They were divided into control group and treatment group，with 15 cases in each group.They were treated with western medicine and traditional Chinese medicine combined with western medicine.They were observed for 24 weeks.The 24-hour urinary protein，serum albumin creatinine and other laboratory indicators were statistically analyzed，and the improvement of patients'symptoms and the change of TCM symptom score were observed to evaluate the efficacy of traditional Chinese medicine in the treatment of membranous nephropathy.Results The total effective rate of the treatment group was 73.3% and that of the control group was 46.7%.The effect was better than that of the simple western medicine group in reducing the 24-hour urinary protein，reducing blood lipid，improving the symptoms of edema，fatigue，waist and knee soreness and numbness，and increasing the total plasma protein and albumin.There was no damage to liver and kidney function before and after treatment.Conclusion The effect of Yiqi Huoxue Lishui traditional Chinese medicine combined with western medicine in the treatment of idiopathic membranous nephropathy of Qi deficiency and blood stasis type is better than that of simple western medicine group.

参考文献/References:

[1]王琳,陈以平.陈以平教师“微观辨证”学术思想在膜性肾病中的应用[J].上海中医药大学学报，2006,20（3）:29-31.
[2］周盈,宋子威,谢璇,等.中医对特发性膜性肾病发病机制的认识[J].中华中医药杂志,2020,35(11):5662-5664.
[3］王海燕.肾脏病学[M].北京：人民卫生出版社,2008:1032.
[4］叶任高，陆再英.内科学[M].6版.北京:人民卫生出版社，2005:508-516．
[5］梅长林．对特发性膜性肾病治疗的评价[J]．中华肾脏病杂志，2004，20(5)：309-310.
[6］高学敏.中药学[M].北京:中国中医药出版社,2002:219-220,502-503.
[7］郑筱萸.中药新药临床研究指导原则[M].中国医药科技出版社,2002:156-162.
[8］李朝玲,董晓静.李锋教授临证辩治“肾性血尿”经验[J].中国中西医结合肾病杂志，2018,3（19）：192-193.
[9］张晓丹,邓跃毅.中医医家辨治膜性肾病经验探析[J].现代中西医结合杂志，2017，26(1):112-114．
[10］陈以平,邓跃毅,倪兆慧,等.中医方案治疗特发性膜性肾病肾病综合征的前瞻性、随机、对照、多中心临床研究[J].中国中西医结合肾病杂志，2012，13（6）：471-474.
[11］王金平,何永生.从“血不利则为水”谈肾病综合征的中医治疗[J].湖南中医杂志，2014,3（30）：98-99.
[12］孙鹏.膜性肾病中医治法探析[J].上海中医药杂志,2013,47(7):6-8．
[13］余仁欢,聂莉芳教授治疗膜性肾病的经验[J].西部中医,2011,24(9):25-27.
[14］Chen Y,Deng Y,Ni Z,et al.Efficacy and safety of traditional Chinese medicine（Shenqi particle）for patients with idiopathic membranous nephropathy：A multicenter randomized controlled clinical trial[J].Am J Kidney Dis,2013,62（6）:1068-1076.
[15］苗明三.怀山药多糖对小鼠免疫功能的增强作用[J].中药药理与临床，1997，13（3）：25-26.
[16］张慧儒,吕会新,康希等.茯苓多糖抗2型糖尿病肾病大鼠肾间质纤维化作用研究[J].当代医学，2016,22（8）:1-2.
[17］董晓静，郭亮锋.丹参调节肾组织AQP2效应与其“活血利尿”关系[J].中国中药杂志，2014,16（8）：3162-3165.
[18］孙健,腊岩.丹参及其组分的药理作用以及在肾脏病的最新应用进展[J].中国中西医结合肾病杂志，2010，11（1）：89-91.
[19］赵润生,张一昕,苗冬雪，等.生地黄对血瘀模型大鼠血液流变性的影响[J].中药药理与临床,2006,22(3-4):123.
[20］陈娟,张明华,章丽，等.牡丹皮苷/酚组分对糖尿病肾病大鼠肾损伤的保护作用及其机制研究[J].中国中药杂志,2016,41（11）:1990-1998.
[21］杨梦凡,贠捷,宋业旭，等,基于网络药理学探究水陆二仙丹治疗膜性肾病作用机制[J].辽宁中医药大学学报，2020,22(11):130-134.
[22］张佳佳,何志涛.玉米须多糖药理作用的研究进展[J].吉林医药学院学报,2021,42(1):62-64.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目（81273622）
更新日期/Last Update: 2022-04-08