[1]李姗姗 孙倩 杨少宁 于小勇.肠道菌群失调与慢性肾脏病关系研究[J].现代中医药,2022,1(03):016-21.[doi:10.13424/j.cnki.mtcm.2022.03.003]
 LI Shanahan SUN Qian YANG Shaoning YU Xiaoyong.Relationship Between Intestinal Flora Imbalance and Chronic Kidney Disease[J].Modern Traditional Chinese Medicine,2022,1(03):016-21.[doi:10.13424/j.cnki.mtcm.2022.03.003]
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肠道菌群失调与慢性肾脏病关系研究
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
1
期数:
2022年03期
页码:
016-21
栏目:
述 评
出版日期:
2022-06-10

文章信息/Info

Title:
Relationship Between Intestinal Flora Imbalance and Chronic Kidney Disease
文章编号:
1672-0571(2022)03-0016-06
作者:
李姗姗1 孙倩1 杨少宁1 于小勇2
1.陕西中医药大学,陕西 咸阳 712046;
2.陕西省中医医院,陕西 西安 710003
Author(s):
LI Shanahan1 SUN Qian1 YANG Shaoning1 YU Xiaoyong2
1.Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;
2.Shaanxi Hospital of Chinese Medicine,Xi'an 710003,China
关键词:
关键词:慢性肾脏病肠道菌群失调微生态制剂粪菌移植中医药
Keywords:
Key words:Chronic kidney diseaseImbalance of intestinal floraProbioticsFecal bacteria transplantationTraditional Chinese Medicine
分类号:
R265.5
DOI:
10.13424/j.cnki.mtcm.2022.03.003
文献标志码:
A
摘要:
摘 要:近年来,慢性肾脏病(chronic kidney disease,CKD)越来越成为全球性的公共健康问题,在中国乃至全世界范围内的疾病负担逐渐加重。现代很多研究证实,肠道菌群失调与很多疾病都存在相关性,肠道菌群失调与慢性肾脏病的关系也成为研究的热点。CKD患者由于尿毒症毒素在体内的蓄积,改变了肠道菌群的结构和组成,破坏了肠道上皮的屏障功能,激活了肠道的免疫调节功能,使得细菌和毒素等有害物质入血,诱导全身性的病变,最终损害肾脏,形成恶性循环。而益生菌等微生态制剂、粪菌移植、中医药等干预手段通过稳定肠道菌群,修复肠道上皮黏膜的屏障功能,减少肠源性尿毒素的蓄积,延缓CKD进展,发挥肾脏保护的作用。因此,调节肠道菌群紊乱可能作为防治CKD的新靶点。
Abstract:
Abstract:In recent years,chronic kidney disease (CKD) has increasingly become a global public health problem,and the disease burden is gradually increasing in China and even all over the world.Many modern studies have confirmed that there is a correlation between intestinal flora imbalance and many diseases.The relationship between intestinal flora imbalance and chronic kidney disease has also become a research hotspot.Due to the accumulation of uremic toxin in the body,CKD patients change the structure and composition of intestinal flora,destroy the barrier function of intestinal epithelium,activate the immune regulation function of intestinal tract,make harmful substances such as bacteria and toxins enter the blood,induce systemic lesions,and finally damage the kidney and form a vicious circle.Probiotics and other probiotics,fecal bacteria transplantation,traditional Chinese medicine and other intervention methods can stabilize the intestinal flora,repair the barrier function of intestinal epithelial mucosa,reduce the accumulation of enterogenous urotoxin,delay the progress of CKD and play the role of renal protection.Therefore,regulating intestinal flora disorder may be a new target for the prevention and treatment of CKD.

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备注/Memo

备注/Memo:
基金项目:陕西省科技厅社发攻关一般项目(2017SF-298);西安市科技计划项目(2019114613YX001SF044)
更新日期/Last Update: 2022-05-30