[1]陈丽 郑玉玲.郑玉玲教授治疗卵巢癌用药规律分析[J].现代中医药,2022,1(06):073-81.[doi:10.13424/j.cnki.mtcm.2022.06.015]
　CHEN Li ZHENG Yuling.Analysis of Professor ZHENG Yuling’s Medication Rule for Ovarian Cancer[J].Modern Traditional Chinese Medicine,2022,1(06):073-81.[doi:10.13424/j.cnki.mtcm.2022.06.015]
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郑玉玲教授治疗卵巢癌用药规律分析
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
1
期数:
2022年06期
页码:
073-81
栏目:
临床精粹
出版日期:
2022-12-10

文章信息/Info

Title:
Analysis of Professor ZHENG Yuling’s Medication Rule for Ovarian Cancer
文章编号:
1672-0571(2022)06-0073-09
作者:
陈丽1 郑玉玲2
1.河南中医药大学第一附属医院，河南 郑州 450000；
2.河南中医药大学，河南 郑州 450000
Author(s):
CHEN Li1 ZHENG Yuling2
1.The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;
2. Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China
关键词:
关键词：郑玉玲; 卵巢癌; 攻补兼施; 以后天养先天; 用药以“平”为期
Keywords:
Key words:ZHENG Yuling;  Ovarian cancer;  Attack and tonifying simultaneously;  Acquired natural endowment;  The medication is “regulation”
分类号:
R285.6
DOI:
10.13424/j.cnki.mtcm.2022.06.015
文献标志码:
A
摘要:
摘 要：目的 运用数据挖掘方法分析总结提炼郑玉玲教授治疗卵巢癌的思想。方法 收集郑玉玲教授门诊治疗卵巢癌的处方，组建数据库，采用频数、聚类分析、关联规则及核心药对复杂网络分析等对方剂及高频中药进行分析。结果 在契合纳入条件的46例医案中，频数最高的前5位方剂：五积散、当归芍药散、薯蓣丸、桃核承气汤、桂枝茯苓丸；将五积散主症标准化，归纳其治疗卵巢癌的症状特点。共涉及中药140味，累积次数803次，用药类别以温补脾肾，活血化瘀，利水祛湿为主。药性以温性居多，药味以甘味最多，药物归经以脾经、肺经、肝经居多。关联规则分析显示常用药对21条，系统聚类分析得到5类。复杂网络分析得到以“茯苓”“当归”为中心的2个模块群。结论 郑玉玲教授认为卵巢癌病机属正虚邪实，治疗上以扶正祛邪为原则，尤其重视脾肾的调治；祛邪以健脾祛湿、行气利水、活血化瘀为主要治法，配合使用清利下焦湿热的药物。在攻邪时较少使用药性峻猛药物，多应用缓急、缓下的方法，以达到祛邪而不伤正的目的。在攻邪的同时多配合使用扶助正气的药物，很少使用纯粹祛邪方剂。
Abstract:
Abstract：Objective To analyze and summarize Professor ZHENG Yuling’s idea of treating ovarian cancer by data mining. Methods Collect the prescriptions of Professor ZHENG Yuling for ovarian cancer in the outpatient department, establish a database, and use frequency, cluster analysis, association rules and core drugs to analyze the prescription and high-frequency Chinese medicine such as complex network analysis.Results Among the 46 medical cases eligible for inclusion, the top 5 prescriptions with the highest frequency were Wuji Powder, Danggui Shaoyao Powder, Shuyu Pill, Taohe Chengqi Decoction, Guizhi Fuling Pill; The main symptoms of Wuji Powder were standardized, and the symptom characteristics of its treatment for ovarian cancer were summarized. A total of 140 traditional Chinese medicines were involved, with a cumulative number of 803 times. The drugs were mainly used to warm the spleen and kidney, promote blood circulation and remove blood stasis, and promote water and damp. Most of the drugs are warm, most of the drugs are sweet, and most of the drugs belong to spleen, lung and liver meridians. Association rule analysis showed that there were 21 drug pairs in common use, and 5 types were obtained by cluster analysis. The complex network analysis obtained two module groups centered on “Poria cocos” and “Angelica sinensis”.Conclusion Professor ZHENG Yuling believes that the pathogenesis of ovarian cancer belongs to the deficiency of vital energy and the excess of pathogenic factors; The main therapeutic methods for dispelling evils are invigorating the spleen and removing dampness, promoting Qi and water circulation, promoting blood circulation and removing blood stasis, and the drugs for clearing away dampness and heat in the lower energizer are used together. When attacking evils, it is less to use harsh drugs, and more to use the method of urgency and slowness, so as to achieve the goal of eliminating evils without harming the origin. At the same time of attacking evils, we should use more medicines to help the healthy Qi, and rarely use pure dispelling prescriptions.

参考文献/References:

［1］李宁,吴令英.中国临床肿瘤学会《卵巢癌诊疗指南(2021年版)》更新要点［J］.中国实用妇科与产科杂志,2021,37(7),720-723.
［2］国家药典委员会.中华人民共和国药典［S］.三部.北京:中国医药科技出版社,2015.
［3］高学敏.中药学［M］.北京:中国中医药出版社,2002.
［4］王泽茜,赵院院,曹明卓,等.基于关联规则和聚类分析的中药治疗崩漏用药规律研究［J］.中药药理与临床,2021,37(4):208-213.
［5］刘保松,白明,苗明三.基于关联规则和因子分析研究糖尿病肾病中药组方用药规律［J］.中国现代应用药学,2019,36(7):781-785.
［6］王光耀,许光兰,陈小丽,等.基于数据挖掘和网络药理学的古方治疗肺结核的用药规律及机制分析［J］.世界科学技术-中医药现代化,2020,22(7):2256-2268.
［7］代彦林,吕晓颖,高敏,等.基于数据挖掘分析丁樱教授治疗紫癜性肾炎的用药规律及思想［J］.辽宁中医杂志,2021,48(2):9-13,225.
［8］武凤震,赵文光.基于数据挖掘的癫痫用药规律探索［J］.中国实验方剂学杂志,2017,23(8):190-195.
［9］吴红英,许光兰,赵媚,等.基于数据挖掘的全国各地区运用中医药防治新型冠状病毒肺炎的用药规律研究［J］.中药药理与临床,2020,36(3):6-11.
［10］饶健,蔡光先,李丹丹,等.五积散的临床和药理作用研究进展［J］.湖南中医药大学学报,2009,29(5):75-77.
［11］刘敏,任存霞.当归芍药散的实验研究进展［J］.中医药学报,2019,47(5):117-119.
［12］徐忠可.金匮要略论注［M］.邓明仲,张家礼点校.北京:人民卫生出版社,1993.
［13］曹毅君.经方当归芍药散在妇科疾病中的应用探究［J］.中国当代医药,2019,26(36):178-181.
［14］罗忠.桃核承气汤妇科运用举隅［J］.浙江中医杂志,1997,32(1):17.
［15］李宝华,李志焕,马阳春.胡思荣应用经方治疗初产妇产后抑郁经验［J］.河南中医,2016,36(11):1883-1884.
［16］刘伟平,滕秀香.当归芍药散联合薏苡附子败酱散治疗盆腔炎性疾病后遗症的临床研究［J］.中国临床医生杂志,2020,48(1):118-121.
［17］阳国彬,刘玉芳.薯蓣丸治疗癌因性疲乏的临床观察［J］.中国中医药科技,2016,23(2):216-217.
［18］夏克春,曾永蕾,郝皖蓉.薯蓣丸治疗癌性疲乏的临床疗效观察［J］.中日友好医院学报,2018,32(5):288-289,292.
［19］乔红丽,侯炜,李站,等.朴炳奎治疗卵巢癌辨证思路及用药规律总结［J］.北京中医药,2014,33(10):735-738.
［20］徐林,张巧丽,姜欣,等.黄金昶治疗卵巢癌的辨证思路及用药经验［J］.北京中医药,2018,37(12):1149-1151.

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备注/Memo

备注/Memo:
基金项目：国家中医药领军人才支持计划-岐黄学者（国中医药人教涵
［2018］284号）
更新日期/Last Update: 2022-11-28