[1]呼延昕娜,呼兴华,王晓琳,等.《千金方》治疗消渴用药规律数据挖掘[J].现代中医药,2023,(01):031-35.[doi:10.13424/j.cnki.mtcm.2023.01.006]
 HUYAN Xinna HU Xinghua WANG XiaolinLU FenpingXU JianqinGAO Yuan.Data Mining of Drug Law of Qian Jin Fang in Treating Diabetes[J].Modern Traditional Chinese Medicine,2023,(01):031-35.[doi:10.13424/j.cnki.mtcm.2023.01.006]
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《千金方》治疗消渴用药规律数据挖掘()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年01期
页码:
031-35
栏目:
出版日期:
2023-01-20

文章信息/Info

Title:
Data Mining of Drug Law of Qian Jin Fang in Treating Diabetes
文章编号:
1672-0571(2023)01-0031-05
作者:
呼延昕娜1呼兴华2王晓琳2卢芬萍2许建秦2高原2
1.宁夏医科大学,宁夏 银川 750000;
2.陕西省中医药研究院,陕西 西安 710003
Author(s):
HUYAN Xinna 1HU Xinghua 2WANG Xiaolin2LU Fenping2XU Jianqin2GAO Yuan2
1.Ningxia Medical University,Yinchuan 750000,China;
2.Shaanxi Academy of Chinese Medicine,Xi’an 710003,China
关键词:
消渴千金方寒温并用数据挖掘
Keywords:
DiabetesQian Jin FangCold and warmData mining
分类号:
R255.4
DOI:
10.13424/j.cnki.mtcm.2023.01.006
文献标志码:
A
摘要:
目的 整理两部《千金方》中治疗消渴的内服方剂并探索其用药规律。方法 借助《中华医典》(V5)筛选《千金方》中治疗消渴的内服方剂,形成文本数据并录入中医传承辅助系统平台(V3.0)进行频数分析、关联规则等分析。结果 共收集方剂80首,涉及中药143味。使用频次较高的药物为天花粉(34次,42.5%)、甘草(22次,27.5%)、茯苓(22次,27.5%)、麦冬(22次,27.5%)、黄连(17次,21.3%)、地黄(15次,18.8%)、桂枝(12次,15.00%)等,对应药性以寒(30.5%)、温(22.2%)为主,药味以甘(52.8%)、苦(31.6%)为主;药物功效频次较高的前三类药物为补虚(24.1%)、清热(17.6%)、渗湿(7.6%);关联规则分析得出13组支持度≥8的高频药对,前三位分别为天花粉→甘草、茯苓→人参、茯苓→甘草;8条置信度≥0.7的关联规则,前四位相关药物分别为“甘草,麦冬→茯苓”“生姜→甘草、天花粉”“麦冬→茯苓、天花粉”“甘草→茯苓”。结论 《千金方》治疗消渴病以养阴、清热、健脾为主要方法,甘苦并用,清补结合,值得借鉴。
Abstract:
Objective To sort out the oral prescriptions for diabetes in two Qian Jin Fang and explore the regularity of their use.Methods With the help of Zhong Hua Yi Dian (V5),we screened the internal prescriptions for diabetes in Qian Jin Fang,formed text data and entered them into the traditional Chinese medicine inheritance assistance system platform (V3.0) for frequency analysis,association rules and other analysis.Results A total of 80 prescriptions were collected,involving 143 Chinese herbs.The frequently used drugs are Trichosanthin (34 times,42.5%),Licorice (22 times,27.5%),Poria cocos (22 times,27.5%),Ophiopogon japonicus (22 times,27.5%),Coptis chinensis (17 times,21.3%),Rehmannia glutinosa (15 times,18.8%),Cinnamon twig (12 times,15.00%),etc.The corresponding drug properties are mainly cold (30.5%),warm (22.2%),and the drug flavors are mainly sweet (52.8%) and bitter (31.6%);The first three kinds of drugs with higher efficacy frequency were tonic (24.1%),heat clearing (17.6%) and moisture permeability (7.6%);Association rule analysis showed that 13 groups of high-frequency drug pairs with support ≥8,the first three were respectively Trichosanthin → Licorice,Tuckahoe →Ginseng,Tuckahoe →Licorice;There are 8 association rules with confidence ≥ 0.7.The first four related drugs are “Licorice,Ophiopogon japonicus → Tuckahoe”,“Ginger →Licorice,Trichosanthin”,“Ophiopogon japonicus →Tuckahoe,Trichosanthin”,“Licorice →Tuckahoe”.Conclusion Qian Jin Fang is mainly used to nourish Yin,clear heat and strengthen the spleen in treating diabetes,which is worth learning from.

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备注/Memo

备注/Memo:
基金项目:国家中医药管理局医史文献重点学科建设单位项目[国中医药发(2009)30号]; 北京中医药大学孙思邈研究院科研计划项目(SSMYJY2202013)
更新日期/Last Update: 2023-01-20