[1]赵宏高王晶 王朋辉 方莹莹 邢晨 席丹丹.半夏厚朴汤加味联合盐酸氟西汀治疗冠心病心绞痛伴抑郁患者有效性临床研究[J].现代中医药,2023,(06):059-63.[doi:10.13424/j.cnki.mtcm.2023.06.013]
　ZHAO Honggao WANG Jing WANG Penghui FANG Yingying XING Chen XI Dandan.linical Study on the Efficacy of Modified Banxia Houpu DecoctionCombined with Fluoxetine Hydrochloride in the Treatment of Patients with Coronary Heart Disease and Angina Pectoris and Depression[J].Modern Traditional Chinese Medicine,2023,(06):059-63.[doi:10.13424/j.cnki.mtcm.2023.06.013]
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半夏厚朴汤加味联合盐酸氟西汀治疗冠心病心绞痛伴抑郁患者有效性临床研究()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年06期
页码:
059-63
栏目:
出版日期:
2023-12-08

文章信息/Info

Title:
linical Study on the Efficacy of Modified Banxia Houpu DecoctionCombined with Fluoxetine Hydrochloride in the Treatment of Patients with Coronary Heart Disease and Angina Pectoris and Depression
文章编号:
1672-0571(2023)06-0059-05
作者:
赵宏高1王晶1 王朋辉1 方莹莹1 邢晨2 席丹丹2
1.宝鸡高新医院，陕西 宝鸡 721000；
2.宝鸡第三医院，陕西 宝鸡 721000
Author(s):
ZHAO Honggao1 WANG Jing1 WANG Penghui1 FANG Yingying1 XING Chen2 XI Dandan2
1 Baoji High tech Hospital, Shaanxi Baoji 721000,China;
2 Baoji Third Hospital, Shaanxi Baoji 721000,China
关键词:
关键词：半夏厚朴汤; 盐酸氟西汀; 冠心病心绞痛; 抑郁; 神经递质
Keywords:
Key words:Banxia Houpu decoction;  Fluoxetine hydrochloride;  Coronary heart disease and angina pectoris;  Depression;  Neurotransmitters
分类号:
R256.22
DOI:
10.13424/j.cnki.mtcm.2023.06.013
文献标志码:
A
摘要:
摘 要：目的 探究半夏厚朴汤加味联合盐酸氟西汀治疗冠心病心绞痛伴抑郁患者的疗效。方法 选取2020年3月—2022年3月宝鸡高新医院接纳的冠心病心绞痛伴抑郁患者88例，随机分为治疗组与对照组，各44例，均接受常规西药治疗，对照组予以盐酸氟西汀，治疗组予以盐酸氟西汀联合半夏厚朴汤加味治疗，评估临床疗效，对比两组患者治疗前后心绞痛发作情况及抑郁、焦虑情况，测量两组血清神经递质水平，记录不良反应。结果 治疗组总有效率显著高于对照组（P＜0.05）；治疗后治疗组心绞痛发作次数、持续时间、发作时疼痛视觉模拟法（Visual Analogue Scale,VAS）评分显著低于对照组（P＜0.05）；治疗后治疗组汉密尔顿焦虑量表（Hamilton Anxiety Scale，HAMA）、汉密尔顿抑郁量表（Hamilton depression scale，HAMD）评分显著低于对照组（P＜0.05）；治疗后治疗组血清去甲肾上腺素（noradrenalin，NE）、5-羟色胺（5-hydroxy tryptamine，5-HT）水平显著高于对照组（P＜0.05）；组间不良反应发生率无显著差异（P＞0.05）。结论 半夏厚朴汤加味联合盐酸氟西汀治疗冠心病心绞痛伴抑郁患者可显著改善其心绞痛症状及神经递质水平，缓解患者抑郁、焦虑情绪，且安全性高。
Abstract:
Abstract：Objective To explore the therapeutic effect of modified Banxia Houpu decoction combined with fluoxetine hydrochloride on patients with coronary heart disease angina pectoris and depression.Methods 88 patients with coronary heart disease angina pectoris and depression admitted to our hospital from March 2020 to March 2022 were randomly divided into a treatment group and a control group, with 44 patients in each group receiving conventional Western medicine treatment. The control group received fluoxetine hydrochloride, while the treatment group received fluoxetine hydrochloride combined with modified Banxia Houpu decoction. The clinical efficacy was evaluated, and the incidence of angina pectoris, depression, and anxiety in the two groups of patients before and after treatment were compared, measure the levels of serum neurotransmitters in both groups and record adverse reactions.Results The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05); After treatment, the number of angina attacks, duration, and pain visual analogue scale (VAS) score in the treatment group were significantly lower than those in the control group (P<0.05); After treatment, the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores in the treatment group were significantly lower than those in the control group (P<0.05); After treatment, the serum levels of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) in the treatment group were significantly higher than those in the control group (P<0.05); There was no significant difference in the incidence of adverse reactions between groups (P>0.05). Conclusion The combination of modified Banxia Houpu decoction and fluoxetine hydrochloride can significantly improve the symptoms of angina pectoris and neurotransmitter levels in patients with coronary heart disease and depression, alleviate depression and anxiety, and have high safety.

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备注/Memo

备注/Memo:
基金项目：宝鸡市卫健委市级科研项目（2019-25）
更新日期/Last Update: 2023-11-23