[1]邓茜瑞苏衍进** 王郁金李红艳王惠玲秦刚新赵莉赵秋菊屈云刘鲁豫罗俊婷.津力达颗粒治疗糖尿病前期临床研究[J].现代中医药,2024,(04):056-59.[doi:10.13424/j.cnki.mtcm.2024.04.011]
　DENG XiruiSU YanjinWANG YujinLI HongyanWANG HuilingQIN GangxinZHAO LiZHAO QiujuQU YunLIU LuyuLUO Junting.Clinical Study of Jinlida Granule in the Treatmentof Diabetes in Early Stage[J].Modern Traditional Chinese Medicine,2024,(04):056-59.[doi:10.13424/j.cnki.mtcm.2024.04.011]
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津力达颗粒治疗糖尿病前期临床研究()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2024年04期
页码:
056-59
栏目:
出版日期:
2024-08-28

文章信息/Info

Title:
Clinical Study of Jinlida Granule in the Treatmentof Diabetes in Early Stage
文章编号:
1672-0571(2024)04-0056-04
作者:
邓茜瑞1苏衍进1** 王郁金1李红艳1王惠玲1秦刚新2赵莉2赵秋菊2屈云2刘鲁豫2罗俊婷2
1.陕西中医药大学，陕西 咸阳 712046;
2.陕西中医药大学附属医院，陕西 咸阳 712000
Author(s):
DENG Xirui1SU Yanjin1WANG Yujin1LI Hongyan1WANG Huiling1QIN Gangxin2ZHAO Li2ZHAO Qiuju2QU Yun2LIU Luyu2LUO Junting2
1.Shaanxi University of Chinese Medicine, Shaanxi Xianyang 712046,China;
2.Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi Xianyang 712000, China
关键词:
关键词:糖尿病前期;  津力达颗粒;  糖脂代谢;  胰岛素抵抗; 炎症因子
Keywords:
Key words:Pre diabetes;  Jinlida granules;  Glycolipid metabolism;  Insulin resistance;  Inflammatory factors
分类号:
R587.1
DOI:
10.13424/j.cnki.mtcm.2024.04.011
文献标志码:
A
摘要:
摘 要：目的 观察津力达颗粒对糖尿病前期患者糖脂代谢的影响。方法 选取陕西中医药大学附属医院住院糖尿病前期（气阴两虚证）患者，共 70 例。按随机数字表将患者分为两组，对照组35例，治疗组35 例。干预方法：对照组给予生活方式干预，治疗组在生活方式干预基础上联合津力达颗粒。治疗 12 w后，对比两组相关临床指标的差异性。结果 治疗后，两组患者FPG、2hPG、 HbA1c、FINS、HOMA-IR、TG、LDL－C、BMI、IL-6、ABI指数、中医证候积分均明显下降（P＜0.05）。且治疗组均明显低于对照组（P＜0.05）。结论 津力达颗粒可明显改善糖尿病前期患者糖脂代谢水平，改善胰岛素抵抗，降低炎症水平，改善血液流通情况，取得明显疗效，值得临床推广。
Abstract:
Abstract：Objective To observe the effect of Jinlida granule on glucose and lipid metabolism in patients with pre diabetes.Methods 70 patients with pre diabetes (deficiency of both Qi and Yin) were selected from the Affiliated Hospital of Shaanxi University of Chinese Medicine. According to a random number table, patients were divided into two groups：a control group of 35 cases and a treatment group of 35 cases. Intervention method：The control group received lifestyle intervention, while the treatment group received a combination of Jinlida granules on the basis of lifestyle intervention. After 12 weeks of treatment, compare the differences in relevant clinical indicators between the two groups. Results After treatment, the FPG, 2hPG, HbA1c, FINS, HOMA-IR, TG, LDL-C, BMI, IL-6, ABI index, and traditional Chinese medicine syndrome score of both groups of patients significantly decreased (P<0.05). And the treatment group was significantly lower than the control group (P<0.05).Conclusion Jinlida granule can significantly improve the glucose and lipid metabolism level of patients with pre diabetes, improve insulin resistance, reduce inflammation level, improve blood circulation, and obtain obvious curative effect, which is worthy of clinical promotion.

参考文献/References:

［1］胡彬.糖尿病前期的临床研究进展［J］.中西医结合心血管病电子杂志,2018,6(17):10,14.
［2］中华医学会糖尿病学分会.中国2型糖尿病防治指南(2021年版)［S］.中华糖尿病杂志,2021,13(4):317-318.
［3］郑筱萸.中药新药临床研究指导原则［S］.北京:中国医药科技出版社,2002:233-237.
［4］胡大一,王领军,余金明,等.踝臂指数评价高危患者下肢外周动脉病多中心临床研究［J］.中国医刊,2005,40(1):36-38.
［5］秦伟锋,石岩.糖调节受损临床研究进展［J］.辽宁中医药大学学报,2010,12(9):134-136.
［6］TABK AG,HERDER C,RATHMANN W,et al.Prediabetes:a high-risk state for diabetes development［J］.Lancet,2012,379(9833):2279-2290.
［7］WELSH C,WELSH P,CELIS-MORALES CA,et al.Glycated hemoglobin,prediabetes,and the links to cardiovascular disease:data from UK biobank［J］.Diabetes Care,2020,43(2):440-445.
［8］STEINER G.Lipid lowering in the patients with prediabetes/metabolic syndrome:what is the evidence?［J］.Current Opinion in Lipidology,2008,19(6):585-591.
［9］焦东方,刘爱华,孙晓泽,等.健脾舒胆降浊方治疗胆郁脾虚兼浊瘀型糖调节受损疗效评价及对脂联素,TNF-α,IL-6的影响［J］.中国实验方剂学杂志,2017,23(21):189-193.
［10］陈雨,郑少雄,郝杰,等.白介素6在2型糖尿病大鼠胰岛素抵抗中的作用［J］.中国临床医学,2011,18(1):32-34.
［11］SENN JJ,KLOVER PJ,NOWAK IA,et al.Interleukin-6 induces cellular insulin resistance in hepatocytes［J］.Diabetes,2002,51(12):3391-3399.
［12］徐秀红,姜赛龙,曹力.彩色多普勒超声诊断2型糖尿病下肢动脉病变的临床意义［J］.中国煤炭工业医学杂志,2013,16(4):621-622.
［13］黄守清,尹莲花.快步走与糖调节受损关系的研究进展［J］.糖尿病新世界,2015(22):86-88.
［14］呼兴华,宋子豪,李玲,等.《圣济总录》脾瘅用药及证治规律分析［J］.现代中医药,2020,40(5):22-24.
［15］成功,孙丰雷,冯博.糖尿病前期脾虚湿热证与肠道菌群关系研究［J］.现代中医药,2022,42(4):6-11.
［16］SHI YL,LIU WJ,ZHANG XF,et al.Effect of Chinese herbal medicine jinlida granule in treatment of patients with impaired glucose tolerance［J］.Chinese Medical Journal,2016,129(19):2281-2286.
［17］JIN D,HOU LL,HAN SL,et al.Basis and design of a randomized clinical trial to evaluate the effect of jinlida granules on metabolic syndrome in patients with abnormal glucose metabolism［J］.Frontiers in Endocrinology,2020,11:415.
［18］符必述,刘应,王迎香,等.津力达颗粒中具有降糖功效的多糖含量测定［J］.成都医学院学报,2022,17(2):166-169.
［19］南敏伦,赵昱玮,吕娜,等.人参多糖的化学结构及其降血糖活性研究进展［J］.中国药房,2014,25(47):4506-4508.
［20］公惠玲,李卫平,尹艳艳,等.黄精多糖对链脲菌素糖尿病大鼠降血糖作用及其机制探讨［J］.中国中药杂志,2009,34(9):1149-1154.
［21］杨金颖,孙芳芳.麦冬多糖的药理作用研究［J］.天津药学,2016,28(2):52-55.
［22］刘歌,王辉,赵振彪. 知母功用本草考证及现代药理认识［J］.辽宁中医药大学学报,2018,20(12)：191-194.
［23］李玉珍.基于血清代谢组学研究玄参—苍术对实验性糖尿病大鼠的降糖增效作用［D］.太原:山西省中医药研究院,2021:1-10.
［24］庞雪,刘玉强,刘小丹,等.麸炒苍术不同部位对大鼠脾虚的影响［J］.现代药物与临床,2015,30(7):763-767.
［25］曹颖. 茯苓多糖药理作用的研究［J］.中国现代药物应用,2013,7(13):217-218.
［26］张瓅方,韩华刚,李梦华,等.黄芪、丹参配伍提取物调控大鼠脂质代谢的初步研究［J］.科学技术与工程,2014,14(32):145-148.
［27］陈钊,王莉,田李芳,等.丹参多酚酸盐联合前列地尔治疗糖尿病肾病的效果［J］.现代生物医学进展,2019,19(19):3653-3656.
［28］张娜,李雪嘉,江晓红,等.丹参葛根药对治疗2型糖尿病的药效学研究［J］.广东药科大学学报,2020,36(6):797-802.
［29］陈伟,王之旸,付友娟,等.津力达颗粒对高糖作用下MIN6细胞的保护作用研究［J］.华南国防医学杂志,2022,36(8):594-598.
［30］陈伟,王之旸,付友娟,等.津力达颗粒对高糖作用下小鼠胰岛β细胞增殖和凋亡的影响［J］.医药导报,2022,41(9):1312-1317.
［31］刘妍.基于FGF21/AMPK信号通路探究津力达颗粒对高脂诱导的胰岛素抵抗的改善作用及相关机制［D］.石家庄:河北中医学院,2021:1-7.

备注/Memo

备注/Memo:
基金项目：陕西省科技厅项目（2020SF-336）;陕西中医药大学附属医院课题(2020YSGZZ005)；咸阳市科技局项目（2021ZDYF-SF-0014）
更新日期/Last Update: 2024-07-15