[1]任思思 高如宏.青白散痰搽剂对白癜风模型豚鼠的治疗作用和皮损组织 SOD活力的影响[J].现代中医药,2018,(04):106-108.[doi:10.13424/j.cnki.mtcm.2018.04.034]
 Ren Sisi Gao Ruhong.Effect of Qingbai Santan Embrocation on the Therapeutic Effect of Vitiligo Model in Guinea Pigs and SOD Activity in Skin Lesions[J].Modern Traditional Chinese Medicine,2018,(04):106-108.[doi:10.13424/j.cnki.mtcm.2018.04.034]
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青白散痰搽剂对白癜风模型豚鼠的治疗作用和皮损组织 SOD活力的影响 ()
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《现代中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2018年04期
页码:
106-108
栏目:
药物研究
出版日期:
2018-07-10

文章信息/Info

Title:
Effect of Qingbai Santan Embrocation on the Therapeutic Effect of Vitiligo Model in Guinea Pigs and SOD Activity in Skin Lesions
文章编号:
1672-0571(2018)04-0106-04
作者:
任思思1 高如宏2
1. 宁夏医科大学,宁夏 银川 750004; 2. 宁夏回族医药研究所,宁夏 银川 750021
Author(s):
Ren Sisi 1 Gao Ruhong2
1. Ningxia Medical University,Yinchuan China,750004; 2. Ningxia Hui Medicine Research Institute,Yinchuan China,750021
关键词:
白癜风 青白散痰搽剂 超氧化物歧化酶
Keywords:
vitiligo Qingbai Santan Embrocation SOD
分类号:
R285. 5
DOI:
10.13424/j.cnki.mtcm.2018.04.034
文献标志码:
A
摘要:
目的 探讨回药“青白散痰搽剂”对对苯二酚实验豚鼠白癜风模型的治疗作用和皮损 SOD 活力的影 响。方法 于黑色豚鼠背部去毛皮肤外涂 5% 对苯二酚制备白癜风模型,实验设正常组、模型组、青白散痰搽剂 组和复方卡力孜然酊组。青白散痰搽剂组给予回药青白散痰搽剂治疗,复方卡力孜然酊组给予复方卡力孜然酊 治疗,正常组和模型组给予生理盐水治疗,各组均局部外搽,1 天 2 次,观察 60 天,观察治疗效果,检测各组豚鼠 皮损组织中的超氧化物歧化酶( SOD) 活性。结果 模型组豚鼠可见明显的色素脱落,皮肤多呈苍白斑状,
Abstract:
Objective: To investigate the curative effect of Qingbai Santan Embrocation on guinea pigs with vitiligo induced by hydroquinone and the SOD activity of skin lesions. Method: The vitiligo model was applied with 5% hydroquinone on the polled skin of the black guinea pigs. The experiment was set up in the normal group,the model group,the Qingbai Santan Embrocation group,and the compound kaliganran group. The Qingbai Santan Embrocation group was given the Hui medicine: Qingbai Santan Embrocation,the compound calorie group was given compound kaliganran,the normal group and the white model group were treated with saline,and each group had partial external applies for twice a day for 60 days. The curative effect was then observed and the SOD activity in skin lesions of guinea pigs was detected. Result: Guinea pigs in model group showed obvious pigmentation,and their skin was mostly pale spots,or white hair was present. In each treatment group,the skin on dorsal model site gradually darkened,and the color was brownish black with a small amount of pigmentation with obvious compound color. The levels of SOD in skin lesions of guinea pigs in the Qingbai Santan Embrocation group and the compound kaliranran group were significantly lower than those in the model group ( P < 0. 05) . TheQingbai Santan Embrocation group and the compound kaliranran group tend to be normal. Conclusion: The Qingbai Santan Embrocation has a good therapeutic effect on the experimental vitiligo guinea pig models. The mechanism of the treatment of vitiligo may be related to the reduction of the abnormal SOD activity in the skin lesion of vitiligo and make it tend to be normal.

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备注/Memo

备注/Memo:
收稿日期: 2017 - 11 - 04 编辑: 文颖娟
更新日期/Last Update: 2019-12-09